根据本底半自动化确定肿瘤内靶区:模型实验

发布时间：2018-01-26 06:00

本文关键词： 癌非小细胞肺正电子发射断层显像术体层摄影术 X线计算机氟脱氧葡萄糖F 标准化摄取值肿瘤内靶区　出处：《中国医学影像学杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的根据本底标准化摄取值(SUV)计算肺肿瘤内靶区(ITV)SUV阈值,并评价其可行性。材料与方法 3个空心插件固定在圆桶底部,空心插件与圆桶分别充满55.06 k Bq/ml和5.37 k Bq/ml 18F-FDG溶液以模拟肿瘤与肺组织。以三维运动滑台驱动该模型模拟呼吸运动,最大位移10.9 mm、21.8 mm、43.7 mm。采集模型二维PET/CT图像。记肺本底SUV为±SD,以+3SD作为确定ITV的阈值,以真实ITV和测量ITV的Dice相似系数(DSC)和容积恢复系数(VRC)为评价指标,并与SUV2.5、35%SUVmax、41%SUVmax、a×m SUV70+b×、0.42×(SUVmax+)及Riegel等根据肿瘤体积、靶本底比及肿瘤运动幅度确定SUV阈值的方法进行比较,分析各方法的ITV、DSC和VRC。结果 3个肿瘤模型共9个ITV真实值分别为134.3 ml、166.1 ml、223.5 ml、86.6 ml、108.5 ml、150.7 ml、32.3 ml、43.8 ml、63.6 ml。采用Riegel等的方法测得ITV与真实值差异无统计学意义(t=-0.48,P0.05)。其他6种SUV阈值法测量ITV与真实值差异有统计学意义(t=-5.11~2.76,P0.05)。+3SD和Riegel等的方法制订的ITV的DSC和VRC分别为0.75~0.92、0.69~0.93和0.82~0.97、0.74~0.96,差异无统计学意义(t=-0.73,P0.05),但大于其他5种方法所得值。结论根据本底确定的SUV阈值(+3SD)具有描绘肺癌ITV的潜力,可以为放射治疗提供ITV的参考范围。
[Abstract]:According to the standard uptake value (SUV) calculation of lung tumor target area (ITV) SUV threshold, and evaluate its feasibility. Materials and methods 3 hollow plug is fixed on the bottom of a barrel, and the barrel is filled with 55.06 hollow plug respectively K Bq/ml and 5.37 K Bq/ml 18F-FDG solution to simulate tumor and lung tissue. The 3D motion sliding table driving the model to simulate the respiratory movement, maximum displacement of 10.9 mm, 21.8 mm, 43.7 mm. acquisition model of two-dimensional PET/CT images. The bottom SUV mind lung + SD, with +3SD as the threshold to determine ITV, ITV and ITV Dice of the real measurement of similarity coefficient (DSC) and the volume recovery coefficient (VRC) for the evaluation index, and SUV2.5,35%SUVmax, 41%SUVmax, a * m * SUV70+b, 0.42 * (SUVmax+) and Riegel according to the tumor volume and tumor target background motion amplitude method to determine the threshold of SUV were compared, the analysis methods of ITV, DSC and VRC. results of 3 tumor models were 9 The true value of ITV were 134.3 ml, 166.1 ml, 223.5 ml, 86.6 ml, 108.5 ml, 150.7 ml, 32.3 ml, 43.8 ml, 63.6 ml. measured by the method of Riegel ITV and the true value of the difference was not statistically significant (t=-0.48, P0.05). The other 6 SUV threshold method and the real value measurement ITV the difference was statistically significant (t=-5.11~2.76, P0.05).+3SD and Riegel making method of ITV DSC and VRC were 0.75~0.92,0.69~0.93 and 0.82~0.97,0.74~0.96, the difference was not statistically significant (t=-0.73, P0.05), but higher than the other 5 methods. The conclusion based on the SUV threshold value of the bottom determined (+3SD) has described the lung cancer ITV the potential range of ITV can provide a reference for radiotherapy.

【作者单位】：福建医科大学附属泉州第一医院核医学科;
【基金】：国家自然科学基金项目(30800274)
【分类号】：R734.2;R730.44
【正文快照】： 18F-FDG PET检测肺癌较CT具有更高的灵敏度和特异度,对淋巴结的分期更准确。根据PET/CT制订非小细胞肺癌(non-small cell lung cancer,NSCLC)放射治疗方案并实施治疗的患者,其总生存期较根据CT制订的方案实施治疗者有延长的趋势[1]。美国国家综合癌症网络(national comprehens

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