美沙拉秦口服联合栓剂预防宫颈癌急性放射性直肠炎的效果研究

发布时间：2018-02-09 14:34

  本文关键词： 美沙拉秦 宫颈癌 急性放射性直肠炎　出处：《青海大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:研究美沙拉秦片剂结合栓剂使用在子宫颈癌放射治疗过程中预防急性放射性直肠炎的疗效观察。方法:选取本院肿瘤妇科从2015年01月到2016年09月收住的子宫颈癌行同步放化疗病患56例,行三维适形放射治疗,随机将这些病患分成观察组和对照组各28例。观察组从放疗开始至放疗结束,口服美沙拉秦肠溶片(莎尔福)及美沙拉秦栓(莎尔福)塞肛,具体用法为片剂,1.0 g/次,早、中、晚各一次,栓剂早晚塞肛,0.5 g/次,2次/日。对照组不采取防治手段。若观察组和对照组病患发现有Ⅱ度或者超过Ⅱ度症状时将地塞米松、庆大霉素、蒙脱石散、三乙醇胺乳膏睡前保留灌肠,症状消失后停止使用。将患者血便、里急后重、腹痛、腹泻状况详细记录下来,根据记录下来的数据探讨所有入选病患急性放射性直肠炎发生率、发生时间、发生程度和保留灌肠的次数,并予以比对。结果:1.观察组有11人(39.29%)发生急性放射性直肠炎,对照组有21人(75.00%)发生,两组比较,前者人数较少,P=0.040.05,有统计学差异。2、观察组急性放射性直肠炎发生程度为0度17例,I度5例,II度6例,III度及IV度0例,对照组发生程度0度7例,I度9例,II度11例,III度1例,IV度0例。P=0.040.05,有统计学差异。3.观察组急性放射性直肠炎发生时间(18.18士4.19天),对照组发生时间(14.48士3.95天),两者相比,前者较晚,P=0.0190.05,有统计学差异。4.观察组保留灌肠人数有(3.00±0.775)次,对照组(4.00±1.414)次,两者相比,前者较少,P=0.0150.05,有统计学差异。结论:美沙拉秦口服结合栓剂使用可使急性放射性直肠炎的发生率降低,减轻急性放射性直肠炎的发生程度,并使其发生时间延后。
[Abstract]:Objective: to study the therapeutic effect of mesalazin tablet combined with suppository in the prevention of acute radiation proctitis during radiotherapy for cervical cancer. Methods: select the tumor gynecology from January 2015 to September 2016 in our hospital. 56 patients with cervical cancer received concurrent radiotherapy and chemotherapy. Three dimensional conformal radiotherapy was performed. These patients were randomly divided into two groups: the observation group (n = 28) and the control group (n = 28). The specific usage was as follows: tablet 1.0 g / time, morning, middle and late, and suppositories in the morning and evening. The control group did not take preventive measures. If the patients in the observation group and the control group found symptoms of degree 鈪，

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