自建光声超声双模态成像系统的肿瘤成像分析

发布时间：2018-02-27 21:29

本文关键词： 光声超声双模态成像系统靶向光声造影剂肿瘤成像　出处：《应用声学》2017年05期 　论文类型：期刊论文

【摘要】：现有B超成像可以提供基于声阻抗差异的组织解剖结构信息,而近年来研究发现,光声成像可以提供标记组织成分的分布和功能信息。本文基于商用B超仪和脉冲激光系统建立了光声超声双模态成像系统,实现了超声组织结构成像和光声生物功能的同时成像。首先基于血红蛋白在某些波段的较强吸光性,实现了肿瘤内部组织血管灌注图像;其次用链接有靶向抗体的纳米颗粒作为靶向光声造影剂,对恶性肿瘤边缘和内部的血管以及血管附近的肿瘤组织进行了成像。最终,通过超声和光声的融合图像提供的肿瘤结构信息与光声图像提供的肿瘤功能信息,可以准确识别肿瘤组织。
[Abstract]:Existing B-mode ultrasound imaging can provide information on tissue anatomy based on acoustic impedance differences, and recent studies have found that, Photoacoustic imaging can provide information on the distribution and function of labeled tissue components. In this paper, a dual-mode photoacoustic ultrasound imaging system is established based on commercial B ultrasonic instrument and pulsed laser system. The imaging of ultrasonic tissue structure and photoacousto-biological function is realized. Firstly, based on the strong absorption of hemoglobin in some bands, the vascular perfusion image of tumor inner tissue is realized. Then, using nanocrystalline particles linked to targeted antibodies as targeted photosonographic agents, the peripheral and internal vessels of malignant tumors and tumor tissues adjacent to them were imaged. Tumor tissue can be accurately identified by the information of tumor structure provided by the fusion image of ultrasound and photoacoustic and the information of tumor function provided by photoacoustic image.
【作者单位】：同济大学物理科学与工程学院声学研究所;上海交通大学医学院附属新华医院;同济大学材料科学与工程学院;深圳华声医疗技术有限公司;
【基金】：国家自然科学基金项目(11374231,11574231,11674249) 国家863项目(2012AA022606)
【分类号】：R730.44;TP391.41

【相似文献】