术后刺激性甲状腺球蛋白水平预测分化型甲状腺癌功能性转移灶的价值

发布时间：2018-03-07 23:19

  本文选题：甲状腺肿瘤　切入点：甲状腺切除术　出处：《中国医学影像学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨分化型甲状腺癌(DTC)术后刺激性甲状腺球蛋白(ps-Tg)水平在~(131)I治疗前预测患者功能性转移灶的价值,用于指导~(131)I治疗。资料与方法回顾性分析101例在连云港市第一人民医院行甲状腺全切术及颈淋巴结清扫术的DTC患者,~(131)I治疗前1 d测ps-Tg水平,~(131)I治疗后5~7 d进行~(131)I-SPECT/CT显像。根据~(131)I-SPECT/CT显像判定是否存在功能性转移灶,分为无转移组(M0)和转移组(M1),并通过ROC曲线评估ps-Tg水平预测功能性转移的价值。结果 M1组的ps-Tg水平高于M0组,差异有统计学意义(U=328.00,P0.001),ps-Tg值的ROC曲线下面积为0.870,诊断界值为40.60 ng/ml,敏感度、特异度、准确度分别为72.34%、100.00%、87.13%。结论 ps-Tg水平可作为预测功能性转移的有效指标,可指导~(131)I治疗。
[Abstract]:Objective to investigate the value of the level of stimulating thyroid globulin (s-Tg) in predicting functional metastases in patients with differentiated thyroid carcinoma (DTC) before treatment. Materials and methods 101 patients with DTC undergoing total thyroidectomy and neck lymph node dissection in Lianyungang first people's Hospital were analyzed retrospectively. The level of ps-Tg was measured 1 day before and 57 days after treatment. According to the I-SPECT / CT imaging, we can determine whether there are functional metastases, ROC curve was used to evaluate the value of ps-Tg level in predicting functional metastasis. Results the ps-Tg level in M1 group was higher than that in M0 group. The area under the ROC curve was 0.870, the diagnostic threshold value was 40.60 ng / ml, the sensitivity, specificity and accuracy were 72.340.00% and 87.130.Conclusion the level of ps-Tg can be used as an effective index for predicting functional metastasis and can be used to guide the treatment of PS-Tg.
【作者单位】： 徐州医科大学附属连云港医院 连云港第一人民医院核医学科;
【基金】：连云港市卫生计生科技项目(201610)
【分类号】：R445.1;R730.44;R736.1
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