白细胞介素17及23在慢性放射性肠炎中的表达及临床意义

发布时间：2018-03-24 08:35

本文选题：慢性放射性肠炎　切入点：白细胞介素　出处：《中国现代医学杂志》2017年15期

【摘要】：目的检测白细胞介素17(IL-17)和白细胞介素23(IL-23)在慢性放射性肠炎患者肠黏膜组织中的表达,并分析其表达与疾病的关系。方法纳入31例慢性放射性肠炎为研究对象,选取健康对照30例。对病情的评估采取临床症状和内镜下表现结合的形式。用免疫组织化学法测定IL-17及IL-23的蛋白表达,并分析其与临床特征的关系。结果慢性放射性肠炎中IL-17及IL-23的阳性表达高于正常肠黏膜组织(均P=0.000)。IL-17及IL-23在慢性放射性肠炎患者肠黏膜中的表达与症状积分及内镜评分呈正相关(均P=0.000)。慢性放射性肠炎患者肠黏膜中IL-17与IL-23的表达相关(r=0.731,P=0.000)。结论 IL-17及IL-23在慢性放射性肠炎组织中高表达,且与疾病严重程度呈正相关,提示IL-17/IL-23免疫轴可能参与慢性放射性肠炎的发生、发展。
[Abstract]:Objective to detect the expression of interleukin-17 (IL-17) and interleukin-23 (IL-23) in the intestinal mucosa of patients with chronic radiation enteritis, and to analyze the relationship between the expression and the disease. Methods 31 patients with chronic radiation enteritis were included in this study. 30 healthy controls were selected. The clinical symptoms and endoscopic manifestations were used to evaluate the disease. The protein expression of IL-17 and IL-23 was determined by immunohistochemical method. Results the positive expression of IL-17 and IL-23 in chronic radiation-induced enteritis was higher than that in normal intestinal mucosa (both P=0.000).IL-17 and IL-23) in the intestinal mucosa of patients with chronic radiation-induced enteritis. There was a positive correlation between IL-17 and IL-23 expression in intestinal mucosa of patients with chronic radiation enteritis. Conclusion the expression of IL-17 and IL-23 in chronic radiation enteritis is higher than that in chronic radiation enteritis. There was a positive correlation with the severity of the disease, suggesting that the immune axis of IL-17/IL-23 might be involved in the occurrence and development of chronic radiation enteritis.
【作者单位】：广西医科大学第二附属医院消化内科;
【基金】：广西卫生厅自筹课题(No:Z2013100)
【分类号】：R730.55

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