第3代双源CT低剂量前列腺CT灌注的可行性

发布时间：2018-03-24 10:53

本文选题：第代双源CT　切入点：前列腺　出处：《中国医学科学院学报》2017年01期

【摘要】：目的探讨在第3代双源CT上行低剂量前列腺CT灌注(p CTP)的可行性。方法 9例前列腺特异性抗原升高的患者在接受前列腺活检穿刺前行p CTP。测量病灶与正常前列腺组织的血流量(BF)、血容量(BV)、平均通过时间(MTT)、表面通透性(PS)和达峰时间(TTP)。计算有效剂量(ED)。结果 9例患者中,6例为前列腺癌,3例为前列腺增生伴慢性炎性改变。9例p CTP检查的平均ED为(3.5±0.3)m Sv。前列腺癌的BF(t=4.64,P0.001)、BV(t=3.27,P0.001)和PS(t=3.58,P=0.004)均明显高于正常前列腺组织,TTP(t=-1.26,P0.001)明显低于正常前列腺组织;前列腺增生伴慢性炎性改变的BF(t=3.96,P=0.001)和PS(t=2.91,P=0.021)也明显高于正常前列腺组织,TTP(t=-1.19,P0.001)明显低于正常前列腺组织;前列腺癌的TTP明显低于前列腺增生伴慢性炎性改变(t=-2.56,P=0.049)。结论第3代双源CT可实现低剂量p CTP,前列腺癌、前列腺增生伴慢性炎性改变和正常前列腺组织的BF、PS和TTP存在显著差异。
[Abstract]:Objective to investigate the feasibility of low dose prostatic CT perfusion in the third generation of dual source CT. Methods 9 patients with elevated prostate specific antigen were treated with prostatic biopsy before puncture, and the lesions and normal prostatic prostatitis were measured. The mean transit time (MTT), surface permeability (PSN) and peak time (TTP) were calculated. Results in 9 cases, 6 cases were prostatic carcinoma and 3 cases were prostatic hyperplasia with chronic inflammatory changes. The average Ed of p CTP was 3.5 卤0.3mSv.The mean Ed of prostate cancer was 4.64g / P 0.001 (P 0.001) and 3.58mS0.004 (P 0.001), respectively, which was significantly higher than that of normal prostate tissue (TTP) -1.26P0.001) and significantly lower than that of normal prostate tissue (P < 0.05). BFTX 3.96 P0. 001) and PSN 2. 91 P0. 021) were also significantly higher than those in normal prostatic tissue (TTP) -1.19 (P0. 001), which were significantly lower than those in normal prostatic tissue (P 0. 001). The TTP of prostate cancer was significantly lower than that of benign prostatic hyperplasia with chronic inflammatory changes (P < 0.049). Conclusion the third generation of dual-source CT can achieve significant differences in low dose p CTP, prostate cancer, prostatic hyperplasia with chronic inflammatory changes and normal prostate tissues.
【作者单位】：中国医学科学院北京协和医学院北京协和医院放射科;
【基金】：卫生公益性行业科研专项项目(201402001、201402019)~~
【分类号】：R816.7;R697.3

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