人体颈椎松质骨显微结构和力学性能的区域性差异研究

发布时间：2018-03-30 06:39

本文选题：显微CT　切入点：松质骨　出处：《中国骨质疏松杂志》2017年05期

【摘要】：目的研究人体脊柱松质骨骨骼显微结构和力学性能的区域性差异。方法采集6个人颈椎C5椎体标本,进行显微CT扫描,应用结构参数测量、显微有限元分析、力学参数计算方法,研究人椎体内解剖部位对于结构参数和力学参数测量结果的影响,应用配对t检验比较结构参数和松质骨的表观刚度在不同部位的差异(α=0.05)。结果腹侧和背侧的结构参数仅有杆状骨小梁体积分数(r BV/TV),R-R接头密度(R-R junc),横向骨小梁体积分数(t BV/TV)存在差异,外侧和内侧的结构参数仅有平均骨小梁厚度(p Tb.Th),杆状骨小梁平均厚度(r Tb.Th),P-P接头密度(P-P Junc),R-P接头密度(R-P Junc),纵向骨小梁体积分数(l BV/TV)不存在差异,头侧和尾侧的结构参数均存在明显差异。代表骨质增多的指标,在尾侧均大于头侧,比如骨体积分数(BV/TV),杆状骨小梁体积分数(r BV/TV),板状骨小梁组织分数(p BV/TV),骨小梁厚度(Tb.Th),骨小梁数目(Tb.N)。腹侧和背侧的表观弹性模量没有差异,表观剪切模量存在差异;外侧和内侧的表观弹性模量在非主方向上存在显著差异,在主方向上无显著差异,表观剪切模量无显著差异;头侧和尾侧的表观弹性模量在主方向上存在显著差异。结论(1)在颈椎椎体松质骨,头侧和尾侧的结构参数均存在显著差异,其余部位的结构参数无显著差异。(2)在颈椎椎体松质骨,头侧和尾侧的表观弹性模量在主方向上存在显著差异;此外外侧和内侧的表观弹性模量在非主方向上存在显著差异,在主方向上无显著差异,表观剪切模量无显著差异。
[Abstract]:Objective to study the regional differences in microstructure and mechanical properties of cancellous bone of human spine. To study the effect of anatomical position of human vertebral body on the measurement results of structural parameters and mechanical parameters. The structural parameters and apparent stiffness of cancellous bone were compared by paired t test (伪 0. 05%). Results the structural parameters of ventral and dorsal trabecular trabeculae were only the density of rBV / TVTVTV-R junction and the volume integral of transverse bone trabeculae. There is a difference in the number of NT BV / TVs. The structural parameters of the lateral and medial trabeculae were only the mean trabecular thickness and the mean thickness of the rod-shaped trabeculae and the density of the P-P Juncn R-P junctions and the longitudinal trabecular volume fraction were not different from those of the longitudinal bone trabecular volume fraction (l BV / TV). The structural parameters of the cephalic and caudal sides were significantly different, and the indexes representing the increase of bone mass were larger in the caudal side than in the cephalic side. For example, the bone volume fraction (BV / TVV), the trabecular volume fraction (r BV / TVV), the trabecular tissue fraction (p BV / TVV), the thickness of trabecular bone (Tb 路THR), the number of trabeculae (Tb. NV), the apparent modulus of elasticity in ventral side and dorsal side are not different, but the apparent shear modulus are different. The apparent modulus of elasticity on the outside and the inside has significant difference in the non-main direction, but no significant difference in the main direction, and there is no significant difference in the apparent modulus of shear in the outside direction and the medial direction. There were significant differences in the apparent modulus of elasticity between the head side and the tail side in the main direction. Conclusion the structural parameters of the cancellous bone, the head side and the tail side of the cervical vertebrae were significantly different. There was no significant difference in the structural parameters of the other parts. (2) there were significant differences in the apparent modulus of elasticity between the head and caudal side of the cancellous bone of the cervical vertebrae in the main direction, and the apparent modulus of elasticity in the outside and the medial side in the non-main direction. There is no significant difference in main direction and apparent shear modulus.
【作者单位】：第四军医大学第一附属医院骨科;
【基金】：国家自然科学基金项目(81301292)
【分类号】：R816.8

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