运动干预对改善40-49岁男性心肺耐力的剂量—效应关系研究

发布时间：2018-03-30 09:05

本文选题：体力活动　切入点：心肺耐力　出处：《北京体育大学》2012年博士论文

【摘要】：目的：通过横断面调查和运动干预实验对40-49岁男性体力活动(PA)、心肺耐力(CRF)与代谢综合征(MS)发病率及相关风险因素之间的相关性进行研究。探讨CRF在改善MS风险因素所起的作用。进一步探讨量和强度提高V02max的机制。实验1：CRF、PA与MS发病率以及相关风险因素相关性研究通过对246名无心血管疾病的男性进行PA调查和CRF测试。比较二者与各风险指标之间的相关性。结果：CRF与MS发病率及风险因素具有很高的相关性,CRF水平较高的人群,MS发病率和风险因素的比例减少,其0R风险值下降至0.337-0.873。实验2：不同运动剂量干预对V02max和MS相关风险因素效果影响的研究通过将受试对象随机分为4组,进行12周的运动干预：(1)不运动组(15人)；(2)小量中强度组(16人)；(3)小量大强度组(14人)；(4)大量大强度组(13人)；测试干预前后V02max和血脂指标。结果：运动干预组受试对象V02max均有所提升,分别提高了4、15.8和17.6%,V02max在不同量同强度组增加的幅度相似。量和强度均会对各血脂水平产生一定的影响,大量大强度获得的效益更大。实验3：不同运动剂量干预对CRF效果影响的机制研究通过对受试对象进行干预后,对其血常规、血管软硬度和超声心动等指标进行监测。结果：(1)量和强度均会引起RBC、Hb和baPWV改善,但只有大量大强度组呈显著性差异。(2)量和强度都有利于心肌功能的改善,大强度组收缩能力显著增强：而舒张能力只有在大量大强度组出现显著增强。(3)大强度组a-vDiff显著提高,强度是引起a-vDiff改善的主要因素。结论： (1)CRF要比PA更能预测MS发病率和相关风险因素,并与之呈剂量-效应关系,高水平的CRF更有利于改善MS风险。 (2)强度要比量更有利于V02max提高；强度和量均有利于血脂、血压的改善,大量大强度获得的效益更大。 (3)V02max提高主要在于量和强度引起心功能和动静脉氧分压差的改善,虽然两个大强度组提高V02max的效果相似,但其机制有所不同。 (4)小量大强度V02max提高主要是通过心脏收缩功能和动脉氧分压差的改善引起的。而大量大强度V02max提高却是收缩能力、舒张能力以及外周机制等因素共同作用产生的。
[Abstract]:Objective: to study the relationship between CRF and metabolic syndrome (MS) incidence and related risk factors in men aged 40-49 years old by cross-sectional investigation and exercise intervention experiment. To explore the role of CRF in improving the risk factors of MS. To further explore the mechanism of increasing the quantity and intensity of V02max. A study on the correlation between CRFPA and MS incidence and related risk factors in experiment 1:. A PA survey and a CRF test were conducted in 246 men without cardiovascular disease. The correlation between the two was compared with the risk indicators. Results there was a high correlation between the incidence and risk factors of the disease and the risk factors. The proportion of incidence and risk factors of MS decreased, The risk value of 0R decreased to 0.337-0.873. Experiment 2: effects of different exercise doses on risk factors related to V02max and MS. The subjects were randomly divided into 4 groups. After 12 weeks of exercise intervention, V02max and blood lipid index were measured before and after intervention. Results: the V02max of the subjects in the exercise intervention group was increased, and the V02max of the subjects in the exercise intervention group was increased, and there were 16 patients in the moderate intensity group and 14 patients in the high intensity group, and 13 patients in the high intensity group were tested before and after the intervention, and the results showed that the V02max of the subjects in the exercise intervention group increased, and that of the patients in the exercise intervention group was higher than that in the control group before and after the intervention. The increase of V02max was similar to that of the same intensity group. Both the volume and the intensity had a certain effect on the level of blood lipid, and the benefit of a large amount of high intensity was more than that of the other groups. Experiment 3: mechanism of effect of different exercise doses on the effect of CRF. After intervention, the blood routine, blood vessel hardness and echocardiography were monitored. Results the volume and intensity of 1% could improve the HB and baPWV of RBCs. However, only a large number of high intensity groups showed significant difference. The volume and intensity were beneficial to the improvement of myocardial function. The contractility of the high intensity group was significantly enhanced, while the diastolic ability was significantly enhanced only in a large number of high intensity groups. The strength is the main factor that causes the improvement of a-vDiff. Conclusion:. CRF can predict the incidence of MS and related risk factors better than PA, and has a dose-effect relationship with it. High level of CRF is more helpful to improve the risk of MS. (2) the intensity should be more favorable to the increase of V02max than the quantity, and both the intensity and the quantity are beneficial to the improvement of blood lipids and blood pressure, and the benefit of a large amount of high intensity is greater. The increase of V02max was mainly due to the improvement of cardiac function and arteriovenous oxygen partial pressure difference due to the volume and intensity. Although the effect of two high intensity groups on V02max was similar, the mechanism was different. 4) the increase of small amount of high intensity V02max is mainly caused by the improvement of cardiac systolic function and arterial oxygen partial pressure difference, while a large number of high intensity V02max increases are caused by the combination of systolic ability, diastolic ability and peripheral mechanism.
【学位授予单位】：北京体育大学
【学位级别】：博士
【学位授予年份】：2012
【分类号】：G804.21

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