航天失重条件下药动学研究进展

发布时间：2018-04-01 23:08

本文选题：失重　切入点：药动学　出处：《沈阳药科大学学报》2017年05期

【摘要】：目的近年来我国载人航天事业发展迅速,载人航天飞行实践次数逐渐增加,极大地推动了航天医学的发展。失重是航天员飞行过程中无法摆脱的不利因素,可以引起机体广泛的生理变化,如体液头向分布、血容量变化、胃肠道功能紊乱等,这些改变或可引起药物在机体内的药物动力学变化,进而影响药物的疗效或产生毒性。目前美国航天局的航天用药仍以地面用药规律为指导,这或会导致航天员用药不安全问题。国内外微重力条件下药动学的研究较为少见,且由于实际飞行次数的限制,相关研究大多通过地面模拟实验来实现。方法结合国内外失重药物动力学的研究进展以及本课题组的相关研究,围绕吸收、分布、代谢、排泄四个过程进行综述。结果与结论总结了失重条件下药动学过程的改变规律,以期为载人航天中的药物应用提供更多基础知识和实验数据。
[Abstract]:Objective in recent years, China's manned space program has developed rapidly and the number of manned space flight practice has increased gradually, which has greatly promoted the development of space medicine. Weightlessness is an unfavorable factor that astronauts cannot get rid of in the course of flight. May cause a wide range of physiological changes in the body, such as head distribution of body fluids, changes in blood volume, gastrointestinal dysfunction, and so on, which may cause changes in the pharmacokinetics of drugs in the body. At present, NASA's space drugs are still guided by the law of drug use on the ground, which may lead to unsafe use of drugs by astronauts. Pharmacokinetics studies under microgravity conditions at home and abroad are relatively rare. Due to the limitation of actual flight times, most of the related studies are carried out through ground simulation experiments. Methods combined with the domestic and foreign research progress of weightlessness pharmacokinetics and the related research of our group, it revolves around absorption, distribution and metabolism. Results and conclusions the changes of pharmacokinetic process under weightlessness were summarized in order to provide more basic knowledge and experimental data for the application of drugs in manned spaceflight.
【作者单位】：北京理工大学生命学院;中国中医科学院中药研究所;中国航天员科研训练中心;
【基金】：国家自然科学基金资助项目(81573693) 国家重大仪器专项资助项目(2012YQ12004410,2012YQ04014010) 1226重大资助项目(AWS16J018)
【分类号】：R859

【相似文献】