320排CT双入口灌注参数与肺癌Ki-67表达率的相关性分析

发布时间：2018-04-03 10:15

本文选题：双入口灌注　切入点：肺癌　出处：《临床放射学杂志》2017年08期

【摘要】：目的应用320排CT双入口灌注成像技术,探讨灌注参数与肺癌Ki-67阳性表达率的关系。方法搜集临床经穿刺或术后病理证实的肺癌患者34例,采用东芝320排CT(Aquilion ONE,Toshiba Medical Systems,Otawara,Japan)扫描器对所有患者进行肺部动态容积灌注扫描,运用双入口灌注成像技术(DICTp)进行图像后处理分析得到肺动脉血流量(PF),支气管动脉血流量(BF)及灌注指数(PI);按Ki-67阳性表达率分为高表达(50%)、中表达(26%~50%)、低表达(10%~25%)3组,分析各灌注参数与Ki-67阳性表达率的相关性。结果BF与Ki-67阳性表达率呈正相关(P0.01,r=0.686),PI与Ki-67的阳性表达率呈负相关(P0.05,r=-0.336),PF与Ki-67的阳性表达率无相关性(P0.05)。结论 320排CT双入口灌注成像参数可评价肺癌Ki-67的阳性表达率,从而在术前为临床评估肺癌的生物学行为提供参考。
[Abstract]:Objective to investigate the relationship between perfusion parameters and Ki-67 positive expression rate in lung cancer by using 320-slice CT double-portal perfusion imaging.Methods Thirty-four patients with lung cancer confirmed by puncture or postoperative pathology were examined with Toshiba Medical Toshiba Medical Otawara Japan scanner.The pulmonary artery blood flow (PFF), bronchoarterial blood flow (BFF) and perfusion index (Pi) were obtained by using dual portal perfusion imaging technique (DICTp). According to the positive expression rate of Ki-67, the patients were divided into three groups: high expression group (50%), middle expression group (26%) and low expression group (10% ~ 25%).The correlation between the perfusion parameters and the positive expression rate of Ki-67 was analyzed.Results there was a positive correlation between BF and the positive expression rate of Ki-67. There was a negative correlation between the positive expression rate of Pi and Ki-67. There was no correlation between the positive expression rate of PF and Ki-67.Conclusion the 320-slice CT dual-portal perfusion imaging parameters can be used to evaluate the positive expression rate of Ki-67 in lung cancer and provide a reference for clinical evaluation of the biological behavior of lung cancer before operation.
【作者单位】：郑州大学第一附属医院放射科;郑州大学第一附属医院心内科;
【分类号】：R730.44;R734.2

【参考文献】