ω-3多不饱和脂肪酸对运动疲劳大鼠心肌细胞代谢、抗氧化能力及血清IL-4、IL-6、INF-γ的影响

发布时间：2018-04-05 01:16

本文选题：ω-PUFAs　切入点：心肌细胞　出处：《中国油脂》2017年08期

【摘要】：探讨了ω-3PUFAs对大鼠心肌细胞代谢及血清T-SOD、MDA、血乳酸、LDH、IL-4、IL-6、INF-γ干预作用。将SD大鼠分为安静对照(Rc)组、运动对照(Mc)组、低剂量ω-3PUFAs灌胃(G1)组、中剂量ω-3PUFAs灌胃(G2)组和高剂量ω-PUFAs灌胃(G3)组。对SD大鼠进行8周递增负荷跑台运动复合ω-3PUFAs干预实验。结果表明:实验组大鼠心肌细胞高能磷酸化合物含量高于Mc组;实验组血清T-SOD活力呈现上升趋势;实验组MDA含量呈现下降趋势,G1组与Mc组比较具有显著差异(P0.05),G2、G3组与Mc组比较具有极显著差异(P0.01);实验组血乳酸水平呈现下降趋势,G1、G2组与Mc组比较具有显著差异(P0.05),G3组与Mc组比较具有极显著差异(P0.01);实验组LDH含量呈现上升现象,且LDH含量与ω-3PUFAs剂量呈正相关;实验组大鼠血清IL-4、IL-6、INF-γ水平低于Mc组。不同剂量ω-3PUFAs对大鼠心肌细胞代谢、抗氧化能力及血清IL-4、IL-6、INF-γ具有干预作用。
[Abstract]:The effects of 蠅 -3PUFAs on the metabolism of rat cardiomyocytes and the effects of serum T-SOD MDAand serum lactate LDH4 IL-4 IL-6 INF- 纬 were studied.Sprague-Dawley rats were divided into three groups: the rest control group (Rc), the exercise control group (McC), the low dose 蠅 -3PUFAs gavage group (G1), the middle dose 蠅 -3PUFAs group (G2) and the high dose 蠅 -PUFAs group (G3).The 8 week incremental load treadmill combined with 蠅-3 PUFAs was performed in SD rats.The results showed that the content of high energy phosphates in cardiac myocytes of experimental group was higher than that of Mc group, and the activity of serum T-SOD in experimental group showed an increasing trend.There is a significant difference in MDA content between G1 group and Mc group. There is a very significant difference between G2G3 group and Mc group, and there is a significant difference in blood lactic acid level between G1 group and Mc group in the experimental group. There are significant differences between group G3 and Mc group in blood lactic acid level of G1 group and Mc group (P 0. 05%, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05).There was a significant difference in Mc group (P 0.01), and the LDH content in the experimental group was increased.The concentration of LDH was positively correlated with the dose of 蠅 -3PUFAs, and the level of IL-4 and IL-6INF- 纬 in serum of experimental group was lower than that of Mc group.Different doses of 蠅 -3PUFAs could interfere with the metabolism, antioxidant capacity and serum IL-4 / IL-6INF- 纬 of rat cardiomyocytes.
【作者单位】：新疆师范大学体育学院运动生物化学实验室;济南艾迪康医学检验中心;山东中医药大学基础医学院;
【基金】：国家自然科学基金(31660736) 2016年新疆维吾尔自治区研究生科研创新项目(XJGRI2016106)
【分类号】：R87

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