三维适形调强放疗在海马区保护中的应用

发布时间：2018-04-06 02:09

本文选题：调强放疗　切入点：海马区　出处：《现代肿瘤医学》2016年02期

【摘要】：目的:探讨三维适形调强放疗(IMRT)在海马区保护性放疗中的应用。方法:选择10例肺癌脑转移患者进行CT及MRI定位扫描,并由主治医师勾画出颅脑放疗的靶区,每例患者均由物理师设计两组相同照射野的全脑三维适形调强放疗计划,实验组(A组)为海马区保护性放疗组,对照组(B组)则对海马区受量不做任何限制。两组单次剂量均为3Gy共计放疗10次,最后均以95%PTV体积获得30Gy的处方剂量进行剂量归一,再利用剂量体积直方图(DVH)对两组海马区及全脑受量进行分析,其中海马区受量的分析选择其最大剂量点(D_(max))及体积分别为30%、40%、50%、60%时的照射剂量。结果:和对照组(B组)比较,海马区受量除最大剂量点(D_(max))外,其余数据均显著降低(P0.000 1)。结论:在颅脑肿瘤的放疗中,调强放疗能在保证全脑受量的同时显著降低双侧海马区的受量,但海马区最大剂量点降低不明显。
[Abstract]:Objective: to investigate the application of three-dimensional conformal intensity modulated radiotherapy (IMRT) in protective radiotherapy of hippocampus.Methods: ten patients with brain metastases from lung cancer were selected for CT and MRI scanning, and the target areas of brain radiotherapy were drawn by the attending physician. Each patient was designed by physicists to plan the whole brain three dimensional conformal intensity modulated radiotherapy (IMRT) with the same radiation field.The experimental group (group A) was treated with Hippocampal protective radiotherapy, while the control group (Group B) did not limit the amount of Hippocampal area.The two groups received 10 doses of 3Gy for a total of 10 times. At last, the prescribed dose of 30Gy was obtained by the volume of 95%PTV, and then the dose volume histogram was used to analyze the hippocampal area and the whole brain of the two groups.The maximum dose and volume of the hippocampal area were 30, 50 and 60, respectively.Results: compared with the control group B), the hippocampal area was significantly lower than that of the control group (P 0.000 1) except for the maximum dose of DX.Conclusion: Intensity-modulated radiotherapy can significantly decrease the bilateral hippocampal area, but the maximum dose point of hippocampus is not significant.
【作者单位】：成都军区总医院肿瘤诊治中心放疗科;
【分类号】：R730.55

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