256层螺旋CT结直肠癌灌注成像扫描时间对灌注参数的影响

发布时间：2018-04-09 01:22

本文选题：结直肠癌　切入点：体层摄影术　出处：《临床放射学杂志》2015年04期

【摘要】：目的评估256层螺旋CT结直肠癌灌注扫描时间变化对灌注参数的影响,以获取基于首过效应阶段灌注扫描序列的最佳灌注扫描时间。方法搜集术前经纤维结肠镜检查并由术后病理证实结直肠腺癌病例29例,进行256层螺旋CT全肿瘤灌注检查。每位患者总灌注扫描时间为60.8 s,通过后处理软件由两位放射科医师分别在60.8 s、57 s、53.2 s、49.4 s、45.6 s、41.8 s、38 s测量肿瘤最大层面灌注参数(BF,BV,TTP,PEI)值,观察其变化。将扫描时间60.8 s所测灌注参数分别与扫描时间(57 s、53.2 s、49.4 s、45.6 s、41.8 s、38 s)灌注参数进行配对样本t检验。对不同医师两次分析结果运用Bland-Altman分析进行一致性分析。P0.05为差异具有统计学意义。结果灌注参数(BF,BV,TTP,PEI)值受到总扫描时间影响。扫描时间为60.8 s时,灌注参数BF、BV、TTP、PEI值分别为(34.12±17.83)ml·min-1·100g-1、(14.76±4.99)ml/100g、(18.92±10.22)s、(36.35±14.64)HU。总扫描时间减至41.8 s,其BF值为(40.35±28.52)ml·min-1·100g-1,与60.8 s所测BF值之间差异有统计学意义(P=0.049);总扫描时间减至45.6 s,其TTP值、PEI值分别为(15.23±7.79)s、(33.68±13.72)HU,与60.8 s所测值之间差异有统计学意义(P=0.024;P=0.022)。随着扫描时间缩短,BV值逐渐减小,与60.8s所测BV值之间差异均存在统计学意义(P0.05)。结论基于首过效应法256层螺旋CT结直肠癌灌注成像总扫描时间对灌注参数(BF,BV,TTP,PEI)值有明显影响。总扫描时间46 s左右能够保证BF、TTP及PEI测定的准确性,而BV值的准确测定可能需延长扫描时间。
[Abstract]:Objective to evaluate the effect of perfusion time on perfusion parameters in 256 slice spiral CT scanning of colorectal cancer and to obtain the optimal perfusion scanning time based on the perfusion scan sequence of the first pass effect stage.Methods Twenty-nine cases of colorectal adenocarcinoma were examined by fiberoptic colonoscopy before operation and confirmed by pathology after operation. 256-slice spiral CT was performed on the whole tumor perfusion examination.The total perfusion scanning time of each patient was 60.8 s. The maximum perfusion parameters (BFV, TTP and PEI) were measured by two radiologists at 60.8 s-1, 57 sm, 53.2 ss, 49.4 sm, 45.6 sm, 41.8 sm, 38 s, respectively, and their changes were observed.The perfusion parameters measured at the scanning time of 60.8 s and the perfusion parameters measured at the scanning time of 57 sL 53.2 sL 49.4 sL 45.6 sm 41.8 sm 38 s were matched for t test.Two analysis results of different doctors using Bland-Altman analysis for consistency analysis. P05 as the difference was statistically significant.Results the total scanning time affected the perfusion parameter (BFV).When the scanning time was 60.8 s, the perfusion parameters (BFV / BV / TTPN / PEI) were 34.12 卤17.83)ml / 100g-1g ~ (-1) and 14.76 卤4.99 / 100g ~ (-1) respectively. The perfusion parameters were 18.92 卤10.22 ~ (-1) h ~ (-1) and 36.35 卤14.64 h ~ (-1), respectively.With the shortening of scanning time, the BV value decreased gradually, and there was significant difference between the BV value and the BV value measured at 60.8s (P 0.05).Conclusion based on the first pass effect method, the total scanning time of 256 slice spiral CT perfusion imaging for colorectal cancer has a significant effect on the perfusion parameters and the value of BFV / TTPV / PEI.The total scanning time is about 46 s to ensure the accuracy of BFT-TTP and PEI, but the accurate measurement of BV may need to prolong the scanning time.
【作者单位】：北京中日友好医院放射科;
【分类号】：R735.34;R730.44

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