重组人粒细胞-巨噬细胞集落刺激因子治疗放射性肠炎的临床分析

发布时间：2018-04-16 12:39

本文选题：肠疾病 + 放疗　；参考：《内蒙古医科大学学报》2016年01期

【摘要】：目的:评估和观察重组人粒细胞-巨噬细胞集落刺激因子(rh GM-CSF)灌肠治疗放射性肠炎的安全性和有效性,为放射性肠炎的治疗提供新的临床治疗药物和临床研究资料。方法:采用随机、单盲、治疗前后自身对照的研究方法,将102例放射性肠炎病人随机分为治疗组(A组、32例)、对照组(B组、35例)和联合组(C组、35例)。治疗组采用rh GM-CSF局部保留灌肠21 d,治疗前后进行自身对照,并与对照组(地塞米松加黄连素)及联合组(地塞米松加黄连素加rh GM-CSF)的治疗病例进行对比分析。观察用药前后症状积分,局部不良反应和用药21 d的总有效率。数据处理采用SPSS 16.0统计学软件,P0.05表明有统计学意义。结果:治疗组总有效率93.75%,对照组总有效率68.57%,联合组总有效率92.29%。治疗组与联合组间差异无统计学意义(P=1.0),治疗组与对照组间差异有统计学意义(P=0.013)。用药后出现的局部不良反应主要表现为局部刺激,个别病人出现局部轻微疼痛,可自行消退。结论:重组人粒细胞-巨噬细胞集落刺激因子治疗放射性肠炎安全有效。
[Abstract]:Objective: to evaluate the safety and efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rh GM-CSF) enema in the treatment of radioactive enteritis, and to provide new clinical therapeutic drugs and clinical data for the treatment of radioactive enteritis.Methods: 102 patients with radiation enteritis were randomly divided into treatment group (n = 32) and control group (n = 35) and combined group C (n = 35).The patients in the treatment group were treated with rh GM-CSF local retention enema for 21 days, and compared with the control group (dexamethasone plus berberine) and the combined group (dexamethasone plus berberine plus rh GM-CSF).Symptom score, local adverse reaction and total effective rate of 21 days before and after treatment were observed.Data processing using SPSS 16.0 statistical software (P0.05) showed that there was statistical significance.Results: the total effective rate was 93.75 in the treatment group, 68.57 in the control group and 92.29 in the combined group.There was no significant difference between the treatment group and the combined group, but the difference between the treatment group and the control group was statistically significant.The main local adverse reactions after medication were local stimulation, and individual patients had local mild pain, which could be self-subsided.Conclusion: recombinant human granulocyte-macrophage colony stimulating factor is safe and effective in the treatment of radiation enteritis.
【作者单位】：湖北医药学院附属人民医院肿瘤中心;
【基金】：湖北省自然科学基金(2013CDZ048)
【分类号】：R730.55

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