中国飞行员血脂异常现状的Meta分析

发布时间：2018-04-20 18:03

本文选题：血脂异常 + 患病率　；参考：《华南国防医学杂志》2016年10期

【摘要】：目的通过Meta分析了解中国飞行员血脂异常患病情况。方法系统检索2016-05月份以前的中国知网期刊全文数据总库(China national knowledge infrastructure,CNKI)、万方数据库以及PubMed数据库中有关中国飞行员血脂异常调查的横断面研究。利用随机效应模型合并所纳入文献中血脂异常患病率,并对不同工作领域(军用航空或民用航空)和时期执行亚组分析,采用敏感性分析评价单一研究对结果的影响。结果共纳入27篇文献,总样本量为45 621人,中国飞行员合并血脂异常总患病率为37.6%(95%CI:30.9%~44.3%)。高血清总胆固醇(total cholesterol,TC)、高三酰甘油(triacylglycerol,TG)、低高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、高低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)等血脂异常患病率分别为17.2%(95%CI:12.3%~22.1%)、25.7%(95%CI:22.5%~28.9%)、22.6%(95%CI:18.9%~26.4%)、14.4%(95%CI:9.4%~19.3%)。民用航空飞行员高TC、高TG、低HDL-C、高LDL-C、血脂异常总患病率均高于军用航空飞行员,但仅高TG患病率两者比较差异有统计学意义(P=0.013)。2010/2015年与2003/2009年相比,高TC、高TG、低HDL-C和高LDL-C的患病率均呈上升趋势,但只有低HDL-C两者比较差异有统计学意义(P=0.013)。结论中国飞行员血脂异常患病率较高,应及早对发现的异常情况实施干预。
[Abstract]:Objective to find out the prevalence of dyslipidemia in Chinese pilots by Meta analysis. Methods systematically retrieved the cross-sectional study of the China National Knowledge Infrastructure (CNKI), the Wanfang database and the investigation of blood lipid abnormality in the Chinese flying staff in the PubMed database before 2016-05 months. The incidence of dyslipidemia in the combination of the machine effect model and the analysis of the different work areas (military aviation or civil aviation) and the period executive subgroup were analyzed by the sensitivity analysis to evaluate the effect of the single study on the results. The results were included in 27 articles, with a total sample size of 45621, and the total prevalence rate of dyslipidemia in Chinese pilots. 37.6% (95%CI:30.9%~44.3%). High serum total cholesterol (total cholesterol, TC), high triglyceride (triacylglycerol, TG), low density lipoprotein cholesterol (high density lipoprotein cholesterol, HDL-C), high and low density lipoprotein cholesterol (low), and other abnormal prevalence rates, respectively, were 17.2% I:12.3%~22.1%), 25.7% (95%CI:22.5%~28.9%), 22.6% (95%CI:18.9%~26.4%), 14.4% (95%CI:9.4%~19.3%). The total prevalence rates of high TC, high TG, low HDL-C, high LDL-C, and dyslipidemia in civil aviation pilots were higher than those of military aviation pilots, but the high TG prevalence rate was statistically significant (P=0.013).2010/2015 year compared with 2003/2009 years. The prevalence rates of C, high TG, low HDL-C and high LDL-C were all rising, but only low HDL-C had a significant difference (P=0.013). Conclusion the prevalence rate of dyslipidemia in Chinese pilots was higher, and intervention should be carried out early on the abnormalities found.

【作者单位】：中国民用航空局民用航空医学中心民用航空医学研究所;北京协和医学院研究生院;中国民航总医院检验科;
【基金】：国家自然科学基金项目(U1333132) 中国民用航空局重大科技专项(MHRD20140101)
【分类号】：R856.5

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