CT联合血清肿瘤标记物在鉴别卵巢交界性肿瘤和良性上皮性肿瘤中的应用

发布时间：2018-04-20 18:52

本文选题：卵巢肿瘤 + 体层摄影术　；参考：《重庆医学》2017年25期

【摘要】：目的探讨CT联合血清肿瘤标记物在卵巢交界性肿瘤(BOT)和卵巢良性上皮性肿瘤(BET)中的鉴别诊断价值。方法回顾性分析经手术和病理证实的28例BOT和41例BET患者的CT资料,收集术前血清糖类抗原-125(CA125)、人附睾分泌蛋白4(HE4)、癌胚抗原(CEA)的检测结果,比较两组肿瘤的CT影像特点和血清肿瘤标记物的水平。结果两种肿瘤实性成分、厚分隔、壁结节的出现率差异有统计学意义(χ~2=25.135、5.240、5.066,P0.05);血清CA125水平的差异有统计学意义(Z=3.202,P0.05),但血清HE4、CEA水平的差异无统计学意义(Z=0.330、1.122,P0.05);血清CA125水平鉴别两种肿瘤的最佳临界值、敏感性、特异性分别为42.45U/mL、53.6%、85.4%;实性成分、厚分隔诊断两种肿瘤的总确诊率为78.5%;实性成分、厚分隔、血清CA125水平诊断两种肿瘤的总确诊率为81.2%。结论卵巢上皮性肿瘤出现实性成分、厚分隔及血清CA125水平升高有助于鉴别BOT和BET。
[Abstract]:Objective to evaluate the value of CT combined with serum tumor markers in the differential diagnosis of ovarian borderline tumor (BOT) and benign epithelial ovarian tumor (BET). Methods CT data of 28 cases of BOT and 41 cases of BET confirmed by operation and pathology were analyzed retrospectively. The results of preoperative detection of serum carbohydrate antigen (-125), human epididymal secretory protein (HEC) and carcinoembryonic antigen (CEA) were collected. Ct features and serum tumor markers were compared between the two groups. Results the solid components of the two tumors were thickly separated. There were significant differences in the occurrence rate of mural nodules (蠂 ~ (2 / 2) 25.135n 5.240 ~ 5.066N P0.05), and the difference of serum CA125 level was statistically significant (P < 0.05), but there was no significant difference in serum HE4 ~ (1 +) CEA level (P = 0.3301.122P0.05). The serum CA125 level was the best critical value, sensitivity, and sensitivity for the identification of two kinds of tumors. The specificity was 42.45 U / mL 53.6 and 85.4, the total diagnostic rate of solid components, thick separation and serum CA125 was 78.5, and that of solid components, thick septum and serum CA125 was 81.2 and 81.2, respectively. Conclusion the presence of realistic components, thick septum and elevated serum CA125 levels in epithelial ovarian neoplasms may be helpful in differentiating BOT from BETs.
【作者单位】：重庆医科大学附属第二医院放射科;
【基金】：国家临床重点专科建设项目(国卫办医函[2013]544号)
【分类号】：R730.44;R737.31

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