非小细胞肺癌CT灌注成像与微淋巴管生成的关系

发布时间：2018-04-24 14:45

本文选题：癌 + 非小细胞肺　；参考：《中国医学影像学杂志》2015年09期

【摘要】：目的 CT灌注成像参数与肺癌的病理类型及微血管生成有一定的关系,为进一步判断CT灌注成像参数评价肺癌临床预后的价值,本文探讨非小细胞肺癌(NSCLC)CT灌注成像参数血容量(BV)、血流量(BF)、对比剂到达峰值时间(TTP)和强化峰值(PEI)与微淋巴管密度(MLVD)的关系。资料与方法 100例肺内单发结节患者行CT灌注扫描,其中60例经病理证实为NSCLC,采用免疫组化法观察60例NSCLC患者的MLVD表达,分析NSCLC患者CT灌注参数与MLVD表达的关系。结果 NSCLC患者MLVD在肺癌边缘组织分布最多(25.16±1.28),其次为肺癌中心组织(16.38±3.58),在正常肺组织中分布最少(7.56±4.38),差异有统计学意义(P0.05)。肿瘤BF、BV与肿瘤MLVD计数呈正相关(r=0.643、0.598,P0.01)。结论 CT灌注成像参数BF、BV与NSCLC患者肿瘤微淋巴管生成有关,可在一定程度上预测肺癌的侵袭及转移。
[Abstract]:Objective CT perfusion imaging parameters are related to the pathological type and microvasculature of lung cancer. In order to further judge the value of CT perfusion imaging parameters to evaluate the clinical prognosis of lung cancer, this paper discusses the blood volume (BV) of CT perfusion imaging (BV), blood flow (BF), peak time (TTP) and enhanced peak value (PEI) of non small cell lung cancer (NSCLC). Relationship with microlymphatic tube density (MLVD). Data and methods 100 patients with single pulmonary nodules were scanned by CT, of which 60 cases were confirmed by pathology as NSCLC. The expression of MLVD in 60 patients with NSCLC was observed by immunohistochemistry. The relationship between CT perfusion parameters and MLVD expression in NSCLC patients was analyzed. The results showed that MLVD in NSCLC patients was most distributed in the marginal tissue of lung cancer. More (25.16 + 1.28), followed by central tissue of lung cancer (16.38 + 3.58), in normal lung tissue the least (7.56 + 4.38), the difference was statistically significant (P0.05). Tumor BF, BV and tumor MLVD count is positively correlated (r=0.643,0.598, P0.01). Conclusion CT perfusion imaging is BF, BV and NSCLC patients are related to tumor microlymphatic angiogenesis, to a certain extent. To predict the invasion and metastasis of lung cancer.

【作者单位】：陕西省肿瘤医院CT室;陕西省肿瘤医院肿瘤外科;
【基金】：陕西省科学技术研究发展计划项目(2011K12-05-04)
【分类号】：R734.2;R730.44

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