调强放疗中生物等效均匀剂量优化结果

发布时间：2018-04-30 23:24

本文选题：等效均匀剂量 + 调强放疗　；参考：《中国医学物理学杂志》2016年02期

【摘要】：目的:探讨生物等效均匀剂量优化算法在调强放疗中对正常组织的保护作用,为临床调强计划设计优化提供更好的经验。方法:随机抽取鼻咽癌、食管癌和直肠癌各20例患者作为研究对象,分别对患者设计两组治疗计划进行调强优化。1组对危及器官增设等效均匀剂量(Equivalent Uniform Dose,EUD)生物优化(Plan-EUD)条件限制,另一组进行常规物理参数优化(Plan-noEUD)。采用统计学方法对两组计划正常组织剂量限制作用进行比较。结果:Plan-EUD组优化后腮腺平均剂量为2737 cGy,平均V_(30)为39.5%,平均并发症概率(NTCP)为0.29,Plan-noEUD组优化后相应值分别为3087 cGy、46.2%、0.38。EUD优化平均剂量下降350 cGy,平均V_(30)下降6.7%,NTCP下降0.09,EUD优化明显利于腮腺的保护。结论:生物等效均匀剂量优化算法在大幅提升病灶靶区边缘剂量,提高靶区的适形度和剂量均匀性的同时,可以显著降低正常组织受量,使正常组织得到更好保护。
[Abstract]:Objective: to investigate the protective effect of bioequivalent uniform dose optimization algorithm on normal tissue in intensity modulated radiotherapy (IMRT), and to provide better experience for the optimization of clinical IMRT design. Methods: 20 patients with nasopharyngeal carcinoma, 20 patients with esophageal carcinoma and 20 patients with rectal cancer were randomly selected as study subjects. The patients were selected to design two treatment plans to optimize the condition of Plan-EUD. The other group was optimized by conventional physical parameters. A statistical method was used to compare the effects of normal tissue dose limitation between the two groups. Results the average dose of parotid gland was 2737 cGy, and the average number of venom 30 was 39.5 in the group of: Plan-EUD. The average probability of complication was 0.29. The corresponding values of the optimized average dose of 0.38.EUD were 3087 cGy ~ 46.2g / 0.38.EUD decreased by 350cGy, and the decrease of 6.7NTCP by 0.09cGy was beneficial to the protection of parotid gland. Conclusion: the bioequivalent uniform dose optimization algorithm can significantly increase the edge dose and the conformability and dose uniformity of the target area, at the same time, it can significantly reduce the normal tissue dose, and make the normal tissue better protection.
【作者单位】：南华大学核科学技术学院;江西省肿瘤医院放疗中心;
【基金】：江西省卫生厅科技计划项目(20141125;20155480)
【分类号】：R730.55

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