内脏脂肪体积及常见肥胖指标与非酒精性脂肪肝的相关性研究

发布时间：2018-05-03 03:01

本文选题：非酒精性脂肪肝 + 腹部内脏脂肪体积　；参考：《放射学实践》2017年05期

【摘要】：目的:探讨腹部内脏脂肪(VAT)体积、心外膜脂肪(EAT)体积、腹部皮下脂肪(SAT)体积、脐平面腹腔长短径、体质指数(BMI)、腰围(WC)、SAT脂肪密度、静脉血甘油三酯(TG)、血胆固醇(CH)值与非酒精性脂肪肝(NAFLD)的相关性。方法:44例受检者(11例脂肪肝和33例正常者)行胸腹部CT平扫,记录受检者的身高、体重、性别、年龄、近期的血TG及CH值、慢性病史、饮酒史及用药史。非酒精性脂肪肝定义为平扫CT上肝脏与脾脏的CT值比值CT_(L/S)1。后处理软件半自动测量EAT体积、VAT体积、腹部SAT体积、WC、腹腔的长短径及棘突后皮下脂肪厚度,自动计算出皮下脂肪的CT值;分析相关指标与CT_(L/S)的相关性。比较相关指标在脂肪肝组与正常组中的差异,并对差异有统计学意义的指标采用受试者工作特征(ROC)曲线计算其对NAFLD的诊断效能。结果:相关性分析显示,VAT体积与CT_(L/S)呈中度相关(r=0.551,P0.001),皮下脂肪密度、腹腔短径、血TG值与CT_(L/S)呈弱相关(r=0.375,P=0.012;r=0.390,P=0.0009;r=0.471,P=0.001)。EAT体积、SAT体积、皮下脂肪厚度、腹腔长径、BMI、WC均与CT_(L/S)无显著相关(P0.05)。ROC分析显示VAT体积的曲线下面积(AUC)最大为0.799(95%CI:0.670~0.927),腹部短径的AUC为0.749(95%CI:0.598~0.901),TG的AUC为0.700(95%CI:0.496~0.904),三者之间的AUC差异无统计学意义(P0.05)。结论:VAT体积与NAFLD的相关性最佳,相比临床常用的SAT体积、BMI,WC等指标,VAT体积更能预测NAFLD的发病风险。
[Abstract]:Objective: To investigate the volume of abdominal visceral fat (VAT), epicardial fat (EAT) volume, abdominal subcutaneous fat (SAT) volume, abdominal length of abdominal length, body mass index (BMI), waist circumference (WC), SAT fat density, venous blood triglyceride (TG), blood cholesterol (CH) value and non-alcoholic fatty liver (NAFLD). Methods: 44 subjects (11 cases of fatty liver and 3) 3 cases of normal subjects and abdominal CT plain scan, recorded the subjects' height, weight, sex, age, recent blood TG and CH value, chronic disease history, drinking history and medication history. Non-alcoholic fatty liver was defined as the CT value ratio CT_ (L/S) 1. of the liver and spleen on CT, which was semi automatically measured EAT volume, VAT volume, SAT volume of abdomen, WC, abdominal cavity The CT value of subcutaneous fat was automatically calculated and the correlation between the related indexes and CT_ (L/S) was analyzed. The difference between the related indexes in the fatty liver group and the normal group was compared, and the index of the difference was statistically significant, and the diagnostic efficiency of the NAFLD was calculated by the ROC curve. VAT volume and CT_ (L/S) showed moderate correlation (r=0.551, P0.001), subcutaneous fat density, intraperitoneal short diameter, and TG value of CT_ (L/S) in a weak correlation (r=0.375, P=0.012; r=0.390, P=0.0009; subcutaneous fat thickness, abdominal length). The area under the curve (AUC) is 0.799 (95%CI:0.670~0.927), the AUC of the abdominal short diameter is 0.749 (95%CI:0.598~0.901), the AUC of TG is 0.700 (95%CI:0.496~0.904). The AUC difference between the three is not statistically significant (P0.05). Conclusion: VAT volume and NAFLD are the best. The risk of NAFLD was predicted.

【作者单位】：上海交通大学医学院附属瑞金医院放射科;
【分类号】：R575.5;R816.5

【相似文献】