内源性大麻素系统在运动减控体重中的作用机制研究

发布时间：2018-05-06 08:48

本文选题：内源性大麻素 + 肥胖　；参考：《中国运动医学杂志》2017年02期

【摘要】：肥胖者体内内源性大麻素系统处于过度活化状态,这种异常状态可显著促进能量摄入和脂肪合成过程,并抑制能量消耗和脂肪分解进程,从而加重肥胖程度。内源性大麻素受体抑制剂如利莫那班可显著改善肥胖机体各器官系统的代谢紊乱状态,但由于其对中枢神经系统的副作用风险而退市,这也引起了研究者不断寻求新的利莫那班替代品。多项研究表明:内源性大麻素受体抑制剂对肥胖机体带来的良性改变与长期有氧运动的效果非常相似,同时长期运动还可改善肥胖机体内源性大麻素系统的过度活化状态。本文综合前人研究成果,从肝脏、骨骼肌、脂肪组织等切入,探讨内源性大麻素系统与糖脂代谢的关系及其在运动减控体重中的可能作用,为研究运动减肥机理提供新思路。
[Abstract]:The endogenous cannabinoid system is in an overactivated state in obese people. This abnormal state can significantly promote energy intake and fat synthesis and inhibit energy consumption and fat decomposition process, thus exacerbating the degree of obesity. Endogenous cannabinoid receptor inhibitors such as rimonabine can significantly improve metabolic disorders in various organ systems of obese organisms, but are delisted because of the risk of side effects on the central nervous system. This has also prompted the researchers to continue to seek new alternatives to rimonabant. A number of studies have shown that endogenous cannabinoid receptor inhibitors have similar effects to long-term aerobic exercise, and long-term exercise can also improve the hyperactivation of endogenous cannabinoid system. Based on the previous research results, the relationship between endogenous cannabinoid system and glycolipid metabolism and its possible role in weight reduction and control were discussed from liver, skeletal muscle and adipose tissue, which provided a new idea for studying the mechanism of exercise weight loss.
【作者单位】：上海体育学院上海市人类运动能力开发与保障重点实验室;
【基金】：国家自然科学基金面上项目资助(编号:81472148)
【分类号】：R87

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