非小细胞肺癌VEGF表达与CT能谱成像相关性的初步研究

发布时间：2018-05-12 03:36

本文选题：肺肿瘤 + 放射摄影术　；参考：《临床放射学杂志》2017年08期

【摘要】：目的初步探讨非小细胞肺癌(NSCLC)组织内血管内皮生长因子(VEGF)的表达强度与CT能谱成像定量参数的相关性。方法术前行CT能谱成像且经手术切除病理学检查证实为NSCLC的患者48例,采用Max Vision快捷免疫组织化学染色检测肿瘤组织内VEGF的表达。用单因素方差分析和SLD-t检验对VEGF表达强度不同的患者间能谱参数进行比较;用Spearman等级相关分析观察VEGF表达强度与能谱参数的相关性。结果碘含量、能谱曲线斜率及40 Ke V对应的CT值在VEGF阴性表达与中等阳性表达组间、弱阳性表达与中等阳性表达组间有显著差异,阴性表达与弱阳性表达组间无显著差异。碘含量、能谱曲线斜率和40 Ke V对应的CT值与VEGF表达强度均呈正相关。结论 NSCLC患者CT能谱成像的定量参数能间接反映肿瘤组织血管生成的相关信息,对于肿瘤生长方式、生长速度、转移、预后等反映肿瘤生物学行为的预测可能存在潜在的价值。
[Abstract]:Objective to investigate the correlation between the expression of vascular endothelial growth factor (VEGF) and the quantitative parameters of CT energy dispersive imaging (EDS) in non small cell lung cancer (NSCLC). Methods 48 patients with NSCLC confirmed by excision and pathology were examined with Max Vision fast immunohistochemical staining for the expression of VEGF in tumor tissue. Single factor analysis of variance (ANOVA) and SLD-t test were used to compare the EDS parameters of patients with different VEGF expression intensity, and the correlation between VEGF expression intensity and EDS parameters was observed by Spearman rank correlation analysis. Results there were significant differences in iodine content, slope of energy spectrum curve and CT value of 40Ke V between VEGF negative expression and moderate positive expression group, weak positive expression group and moderate positive expression group, but there was no significant difference between negative expression and weak positive expression group. Iodine content, slope of energy spectrum curve and CT value corresponding to 40 Ke V were positively correlated with the intensity of VEGF expression. Conclusion the quantitative parameters of CT energy dispersive imaging in NSCLC patients can indirectly reflect the information of tumor angiogenesis, and may have potential value in predicting tumor biological behavior, such as tumor growth mode, growth rate, metastasis and prognosis.
【作者单位】：山东大学附属千佛山医院影像科;
【基金】：山东省自然科学基金项目(编号:ZR2015HL096)
【分类号】：R730.44;R734.2

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