美沙拉嗪治疗放射性直肠炎的疗效观察

发布时间：2018-05-17 17:36

本文选题：放射性直肠炎 + 美沙拉嗪　；参考：《山西医科大学》2017年硕士论文

【摘要】：目的:观察美沙拉嗪口服联合栓剂治疗放射性直肠炎的临床疗效。方法:收集2014年9月~2017年1月于山西医科大学第一医院就诊,接受腹、盆部肿瘤放射治疗后发生放射性直肠炎的患者。所有患者均给予美沙拉嗪肠溶片,1g,Tid,Po;美沙拉嗪栓,0.5g,Qd,塞肛,治疗总疗程为5周。观察治疗后总有效率,治疗前后各症状积分、生活质量及血象的变化情况,并对内镜下肠黏膜损伤的情况进行评价,同时记录药物的不良反应。结果:1、美沙拉嗪口服联合栓剂治疗放射性直肠炎,临床治愈例数占25%,显效65%,无效10%,总有效率达90%。2、治疗后患者便血、大便次数增多及医师对症状的整体评价的症状积分较治疗前明显改善(P0.05);腹痛、里急后重及炎症引起的发热治疗前后,差异不明显(P0.05)。3、治疗后KPS评分及PLT值均较治疗前明显提高(P0.05)。4、肠镜下黏膜损伤情况,治疗后明显减轻,差异有统计学意义(P0.01)。5、整个观察期间,患者未发生明显不良反应。结论:美沙拉嗪口服联合栓剂治疗放射性直肠炎,可改善临床症状和提高生活质量,尤其是对大便次数增多及便血的疗效显著,且具有良好的安全性。
[Abstract]:Objective: to observe the clinical effect of mesalazine combined with suppository in the treatment of radiation proctitis. Methods: from September 2014 to January 2017, the patients who were admitted to the first Hospital of Shanxi Medical University and received radiation therapy for abdominal and pelvic tumors were collected. All patients were treated with mesalazine enteric-coated tablets 1 g of Tido Poe and 0.5 g QD of mesalazine suppository for a total treatment course of 5 weeks. The total effective rate, symptom score, quality of life and blood picture before and after treatment were observed, and the injury of intestinal mucosa under endoscope was evaluated, and adverse drug reactions were recorded at the same time. Results in the treatment of radioactive proctitis, 25 cases were cured, 65 were effective, 10 were ineffective, and the total effective rate was 90. 2. After treatment, the patients had hematochezia. The number of stool increased and the integral symptom score of the physician's overall evaluation of symptoms improved significantly than before and after treatment, and the abdominal pain, acute and severe abdominal pain, and fever caused by inflammation were significantly improved before and after treatment. The difference was not significant (P 0.05). The KPS score and PLT value after treatment were significantly higher than those before treatment. The mucosal injury under colonoscopy was obviously alleviated after treatment, and the difference was statistically significant (P 0.01). There was no significant adverse reaction during the whole observation period. Conclusion: the treatment of radioactive proctitis with oral mesalazine combined with suppository can improve the clinical symptoms and quality of life, especially for the increase of stool frequency and hematochezia, and has a good safety.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R730.55

【参考文献】