超声、钼靶X线及其联合应用诊断乳腺癌准确性的Meta分析

发布时间：2018-05-18 09:02

  本文选题：乳腺癌 + 超声　； 参考：《甘肃医药》2016年10期

【摘要】：目的:采用Meta分析方法评价超声、钼靶以及联合应用在乳腺癌诊断中的临床价值。方法:计算机检索Pub Med、Web of Science、The Cochrane Library、万方数据库、中国知网、中国生物医学文献数据库,并辅以手工检索,获取超声和钼靶在乳腺癌诊断的相关文献。依据诊断准确性研究的质量评估(QUADAS-2)工具进行文献质量评价。利用Meta-Disc1.4和Rev Man 5.2软件对超声和钼靶诊断乳腺癌的敏感性(SEN)、特异性(SPE)、阳性似然比(+LR)、阴性似然比(-LR)、诊断比值比(DOR)进行合并分析,并计算综合受试者工作特征(SROC)曲线下面积。结果:Meta分析结果显示,以术后病理检查为金标准,乳腺超声诊断乳腺癌的SEN合并为0.85(95%CI:0.84,0.86),SPE合并为0.93(95%CI:0.92,0.93),DOR为20.35(95%CI:13.62,30.4);钼靶X线诊断乳腺癌的SEN合并为0.81(95%CI:0.80,0.83),SPE合并为0.97(95%CI:0.97,0.97),DOR为19.49(95%CI:11.29,33.66);乳腺超声联合钼靶X线诊断乳腺癌的SEN合并为0.94(95%CI:0.93,0.95),SPE合并为0.93(95%CI:0.92,0.94),DOR为89.24(95%CI:46.14,172.63)。结论:乳腺超声和钼靶X线诊断乳腺癌的准确性较高,两者效果相当,联合应用更能有效地提高诊断乳腺癌的准确性。
[Abstract]:Objective: to evaluate the clinical value of ultrasound, molybdenum target and combined application in the diagnosis of breast cancer by Meta. Methods: the Pub Medence web of the Cochrane Library, Wanfang Database, China knowledge Network, Chinese Biomedical Literature Database were searched by computer, and the relevant documents of ultrasound and molybdenum target in breast cancer diagnosis were obtained by hand search. The literature quality was evaluated according to the QUADAS-2 tool of diagnostic accuracy study. The sensitivity, specificity, positive likelihood ratio (LRN), negative likelihood ratio (NLR) and diagnostic ratio (OR) of ultrasound and molybdenum target in the diagnosis of breast cancer were analyzed by Meta-Disc1.4 and Rev Man 5.2, and the area under the curve was calculated. Results the results of the meta-analysis showed that the postoperative pathological examination was regarded as the gold standard. 涔宠吅瓒呭０璇婃柇涔宠吅鐧岀殑SEN鍚堝苟涓，

本文编号：1905242