体力活动与AD高危人群认知功能

发布时间：2018-05-24 05:41

本文选题：阿尔茨海默病 + 认知　；参考：《北京体育大学学报》2015年08期

【摘要】：2015年ACSM第62届年会EIM专题关于全球人口老龄化的问题,在进一步肯定了积极参与体力活动或规律运动锻炼对健康老年人的认知功能具有促进作用的基础上,提出当存在AD高风险因素诸如APOE-ε4等位基因携带者、已确诊为轻度认知障碍(MCI)或者患有代谢性疾病时,体力活动对于该人群认知功能的影响就更为重要。对近年来关于体力活动或运动锻炼干预对具有罹患AD高危因素人群其认知功能的差异影响、临床表现及大脑结构功能影响做一综述。已有研究结果提示对未来罹患痴呆症具有高遗传性风险因素的人群,运动干预的保护作用较大。运动训练可以有效地稳定MCI患者认知功能,提高AD早期患者心肺适能可以增加其脑容量。APOE-ε4等位基因携带者高强度体力活动可以减少其脑内淀粉样蛋白沉积、激活相关神经回路。随着对运动干预认识的深入,在具有罹患AD的高危人群中,开展运动干预的随机临床试验、行为学检测及神经影像学的变化特征研究将是未来的研究重点。
[Abstract]:The EIM theme of the 62nd annual meeting of ACSM in 2015 on the problem of global population aging, on the basis of further affirming that active participation in physical activity or regular exercise can promote the cognitive function of healthy elderly people. It is suggested that when there are high risk factors for AD, such as APOE- 蔚 4 allele carriers who have been diagnosed with mild cognitive impairment (MCI) or metabolic disease, the effect of physical activity on cognitive function is more important. This paper reviews the effects of physical activity or exercise intervention on cognitive function, clinical manifestation and brain structure function of people with high risk factors of AD in recent years. The results suggest that exercise intervention has a greater protective effect on people with high genetic risk factors for dementia in the future. Exercise training can effectively stabilize the cognitive function of MCI patients, improve the cardiopulmonary fitness of early AD patients can increase the brain volume. APOE- 蔚 4 allele carrier high intensity physical activity can reduce the amyloid deposition in the brain and activate the related neural circuit. With the deepening of understanding of exercise intervention, in the high-risk population with AD, it will be the focus of future research to carry out random clinical trials, behavioral tests and neuroimaging characteristics of motor intervention.
【作者单位】：北京体育大学;
【基金】：国家自然科学基金资助项目(项目编号:31271278) 中央高校基本科研业务费专项资金资助项目(项目编号:2015JX002)
【分类号】：R87

【共引文献】