IGF-1在治疗骨骼肌损伤中的应用潜能及其相关机制

发布时间：2018-05-28 08:04

本文选题：IGF- + 骨骼肌　；参考：《生命的化学》2016年04期

【摘要】：胰岛素样生长因子-1(IGF-1)作为一种生长因子,在骨骼肌损伤后治疗过程中发挥重要的作用。局部注射外源性IGF-1或通过转基因技术使损伤处骨骼肌细胞过表达IGF-1,均能促进损伤骨骼肌再生。IGF-1促进损伤骨骼肌修复的机制可能与如下因素有关:激活骨骼肌卫星细胞,促进成肌细胞增殖与分化,促进蛋白质合成并抑制蛋白分解;抑制骨骼肌炎症反应,并调节巨噬细胞极化;抑制细胞表达胶原蛋白,减少骨骼肌纤维化;作为一种潜在的神经营养因子和生血管因子,促进损伤后的神经和血管再生。因此,IGF-1在骨骼肌损伤后的治疗中具有重要的应用前景。
[Abstract]:As a growth factor, insulin-like growth factor-1 (IGF-1) plays an important role in the treatment of skeletal muscle injury. The mechanism of local injection of exogenous IGF-1 or overexpression of IGF-1 in injured skeletal muscle cells by local injection of exogenous IGF-1 or by transgenic technique could promote the regeneration of injured skeletal muscle. IGF-1 could promote the repair of injured skeletal muscle, which may be related to the activation of skeletal muscle satellite cells. Promote the proliferation and differentiation of myoblasts, promote protein synthesis and inhibit protein decomposition, inhibit the inflammatory response of skeletal muscle and regulate macrophage polarization, inhibit cell expression of collagen, reduce skeletal muscle fibrosis; As a potential neurotrophic factor and angiogenic factor, promote the nerve and vascular regeneration after injury. Therefore, IGF-1 has an important application prospect in the treatment of skeletal muscle injury.
【作者单位】：上海体育学院运动科学学院;
【基金】：国家自然科学基金项目(31300975,31271273) 教育部博士点基金项目(20133156120004) 上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)
【分类号】：R873

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