低剂量HRCT对COPD患者小气道的定量研究
发布时间:2018-05-29 19:35
本文选题:低剂量HRCT + COPD ; 参考:《临床放射学杂志》2017年01期
【摘要】:目的评价低剂量HRCT成像技术对慢性阻塞性肺疾病(COPD)患者小气道研究的可行性。方法选择临床诊断为COPD患者69例,健康对照组20名,通过低剂量HRCT检查及常规肺功能检查,采用完全自动化气道评估软件,分析不同级别COPD患者的低剂量HRCT小气道参数的差异性及小气道参数与常规肺功能参数的相关性。结果最大吸气末扫描:COPD患者Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级的WA/BSA(mm~2/m~2)分别为:21.08±3.70、17.90±3.28、23.30±4.15、20.81±4.16(P=0.014);LA/BSA(mm~2/m~2)分别为:13.64±3.21,10.76±2.24,13.94±3.41,12.35±3.05(P=0.033);TA/BSA(mm~2/m~2)分别为:34.75±6.72、28.66±5.41、37.23±7.82、33.13±7.05(P=0.023);WA%/WV%分别为:61.27±2.75、62.36±1.96、63.27±2.34、63.50±2.18(P=0.009)。各参数组间差异有统计学意义,以WA%/WV%差异更明显。气道定量软件对COPD患者第3级支气管的测量参数与常规肺功能相关性:WA%/WV(%)与肺功能检测参数的FEV1(%pred),FEV1/FVC(%),FEF25%(%pred),PEF(%pred)各参数有好的相关性(r分别为-0.41,-0.45,-0.47,-0.46,P0.01);Pi10 WA(mm2)也与PFT的FEV1(%pred),FEV1/FVC(%),FEF75%(%pred)有好的相关性,(r分别为0.46,0.41,0.48,P0.01)。WA%/WV%与肺功能检测参数的RV,TLC有弱的相关性(r分别为0.28,0.27,P0.05)。结论低剂量HRCT扫描及小气道的定量分析能很好地评估COPD患者的肺功能情况,可作为临床评估COPD患者小气道病变的客观指标。
[Abstract]:Objective to evaluate the feasibility of low dose HRCT imaging in the study of small airway in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 69 patients with COPD and 20 healthy controls were selected. The low dose HRCT test and routine pulmonary function test were used to evaluate the airway function with automatic airway evaluation software. To analyze the difference of small airway parameters of low dose HRCT in patients with different grades of COPD and the correlation between small airway parameters and routine pulmonary function parameters. 缁撴灉鏈,
本文编号:1952130
本文链接:https://www.wllwen.com/yixuelunwen/yundongyixue/1952130.html
最近更新
教材专著