容积螺旋穿梭模式基底节CT灌注参数测量一致性的实验研究

发布时间：2018-06-13 04:01

本文选题：体层摄影术 + 螺旋计算机　；参考：《中国医学影像学杂志》2015年09期

【摘要】：目的脑CT灌注成像(CTP)测量参数的稳定性对于颅脑疾病的正确诊断及评估具有重要意义。本文评价128层CT容积螺旋穿梭(VHS)模式下正常兔脑基底节CTP测量的一致性。材料与方法 10只健康新西兰成年大白兔,采用VHS模式进行颅脑CTP。分别由甲、乙2名放射科医师独立进行CTP后处理,感兴趣区置于基底节,灌注参数测量包括脑血容量(CBV)、脑血流量(CBF)、平均通过时间(MTT)。医师甲间隔30 d后进行第2次后处理及测量。比较两侧基底节灌注参数的差异、不同医师及同一医师2次测量灌注参数的差异,评价2名医师及同一医师2次测量灌注参数的一致性。结果 3次测量两侧基底节CBV、CBF、MTT比较,差异均无统计学意义(F=0.162、0.050、0.488,P0.05)。医师甲、乙首次测量CBV、CBF、MTT值的ICC分别为0.84、0.81、0.79;医师甲前后2次测量CBV、CBF、MTT值的ICC分别为0.80、0.89、0.84,不同医师及同一医师不同时间测量结果一致性较好。结论使用同一后处理软件情况下,VHS模式正常兔脑基底节CTP灌注参数测量一致性较好,提示该方法可用于相关动物模型脑基底节血流动力学研究。
[Abstract]:Objective to evaluate the stability of CT perfusion imaging parameters in the diagnosis and evaluation of craniocerebral diseases. To evaluate the consistency of CTP measurement in normal rabbit basal ganglia under 128 slice CT volumetric spiral shuttle (VHS) model. Materials and methods 10 healthy New Zealand adult rabbits were used to perform brain CTP with VHS model. CTP postprocessing was performed by two radiologists (A and B) respectively. The area of interest was placed in the basal ganglia. The perfusion parameters included CBV volume, CBFV and mean transit time (MTT). The second post-treatment and measurement were performed after 30 days interval. The difference of perfusion parameters between two sides of basal ganglia and the difference of perfusion parameters between different doctors and the same physician were compared, and the consistency of two measurements of perfusion parameters between two physicians and the same physician was evaluated. Results there was no significant difference in MTT between CBVG and CBFU of bilateral basal ganglia. The difference was not statistically significant. The difference was not statistically significant (P 0. 05) between 0. 162 ~ 0. 050 ~ 0. 488g ~ 0. 488g / g. For the first time, the ICC values of CBFV MTT were 0.84 ~ 0.81 ~ 0.79 and 0.800.89 ~ 0.84, respectively. The results of different doctors and the same doctor at different time were consistent. Conclusion using the same post-processing software, the parameters of CTP perfusion in the normal rabbit basal ganglia of VHS model are consistent, which suggests that this method can be used to study the hemodynamics of basal ganglia in related animal models.
【作者单位】：河北医科大学第二医院影像科;
【分类号】：R816.1

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