放疗对结肠癌肝转移患者血清基质金属蛋白酶-2和-9表达的影响

发布时间：2018-06-17 10:58

本文选题：结肠癌 + 肝转移　；参考：《中国老年学杂志》2017年16期

【摘要】：目的观察放疗对结肠癌肝转移患者血清中基质金属蛋白酶(MMP)-2和MMP-9表达的影响,分析其在有无腹水患者中的表达差异。方法观察组为34例结肠癌肝转移患者,在常规化疗基础上加用放疗。选择同期经病理学确诊为结肠癌无血道和淋巴结转移30例为对照组。于治疗前及治疗8 w后抽取空腹静脉血。选择同期经体检证实为无明显器质性疾病的成人血清标本28例作为正常对照组。应用酶联免疫吸附法(ELISA)法检测3组血清中MMP-2和MMP-9的表达。结果观察组、对照组治疗前、治疗后和正常对照组血清中MMP-2、MMP-9表达的差异有统计学意义(P0.05),观察组治疗后血清中MMP-2和MMP-9的下降值明显高于对照组(P0.05)。观察组有腹水组中治疗后血清中MMP-2和MMP-9的下降值明显高于无腹水组(P0.05)。结论放疗对结肠癌伴有肝转移患者有一定的作用,同时能有效下调血清中MMP-2和MMP-9表达,对有腹水患者血清中MMP-2和MMP-9表达的调节可能更明显。
[Abstract]:Objective to observe the effect of radiotherapy on the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 (MMP-9) in serum of patients with liver metastasis of colon cancer, and to analyze the difference of the expression of MMP-2 and MMP-9 in patients with ascites or not. Methods 34 patients with liver metastasis of colon cancer were treated with radiotherapy on the basis of routine chemotherapy. Thirty patients with pathologically diagnosed colon cancer without blood and lymph node metastasis were selected as control group. Fasting venous blood was drawn before and 8 weeks after treatment. A total of 28 adult serum samples with no obvious organic diseases were selected as normal control group. The expression of MMP-2 and MMP-9 in serum of three groups was detected by Elisa. Results there was a significant difference in the expression of MMP-2 and MMP-9 between the observation group, the control group and the control group before and after treatment. The decrease of MMP-2 and MMP-9 in the serum of the observation group was significantly higher than that of the control group after treatment (P 0.05). The levels of MMP-2 and MMP-9 in serum of the observation group with ascites after treatment were significantly higher than those of the non-ascites group (P 0.05). Conclusion radiotherapy has a certain effect on the expression of MMP-2 and MMP-9 in serum of colon cancer patients with liver metastasis, and the regulation of MMP-2 and MMP-9 expression in serum of patients with ascites may be more obvious.
【作者单位】：青海大学附属医院肿瘤放疗科;青海大学附属医院胃肠外科;青海大学附属医院介入科;
【分类号】：R730.55;R735.35

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