12周不同强度运动干预对大鼠心肺耐力的改善效果

发布时间：2018-06-19 01:43

本文选题：心肺耐力 + 运动干预　；参考：《中国运动医学杂志》2017年06期

【摘要】：目的:探究12周不同强度的运动干预对心肺耐力的提升效果,为改善心肺耐力的有效运动负荷评价提供理论支持。方法:40只雄性Wistar大鼠随机分为安静组、小强度组(50%VO2max)、中强度组(65%VO2max)、大强度组(80%VO2max),每组10只。安静组不运动,运动组适应性训练3天后测试最大摄氧量,之后每隔两周测试1次。运动组大鼠每天训练1h,每周5天。12周运动干预后,进行超声心动测试,测试各组大鼠心脏形态学及功能学指标。结果:(1)经过12周训练后,小强度组和大强度组大鼠体重显著低于安静组(P0.05,P0.01)。(2)12周运动干预后,3个运动组大鼠VO2max都显著高于安静组(P0.01)。中强度组和大强度组VO2max提升效果较快,分别在第8周末和第6周末达到峰值。而小强度组在第10周末明显提升,并于12周末达到峰值。(3)大强度组左室收缩末内径显著低于小强度组(P0.05),而射血分数和左室短轴缩短率则显著高于小强度组(P0.05)。结论:(1)不同强度的运动都可以改善大鼠的心肺耐力,但相比中强度和大强度运动,小强度运动对心肺耐力的改善所需的运动干预时间更长。(2)只有大强度运动可以改善心脏泵血功能。
[Abstract]:Objective: to explore the effect of 12 weeks exercise intervention on improving cardiopulmonary endurance, and to provide theoretical support for the evaluation of effective exercise load for improving cardiopulmonary endurance. Methods Forty male Wistar rats were randomly divided into quiet group (n = 10), small strength group (n = 50), middle strength group (n = 65) and high strength group (n = 80). The rest group did not exercise, the exercise group tested the maximal oxygen uptake after 3 days of adaptive training, and then every two weeks. The rats in the exercise group were trained for 1 hour every day, 5 days a week and 12 weeks after exercise, then the echocardiography test was carried out, and the cardiac morphological and functional indexes were measured. Results (1) after 12 weeks training, the body weight of the rats in the small intensity group and the high intensity group was significantly lower than that in the rest group. After 12 weeks of exercise intervention, the VO2max of the three exercise groups was significantly higher than that of the rest group. The effect of VO2max in medium strength group and high intensity group was faster, reaching the peak at the 8th and 6th weekend, respectively. The left ventricular end-systolic diameter in the high-intensity group was significantly lower than that in the low-intensity group, while the ejection fraction and the shortening rate of the left ventricular short axis were significantly higher than those in the low-intensity group. Conclusion (1) exercise of different intensities can improve the cardiopulmonary endurance of rats, but compared with moderate intensity and high intensity exercise, The duration of exercise intervention to improve cardiopulmonary endurance was longer than that of low intensity exercise) only high intensity exercise could improve cardiac pump function.
【作者单位】：成都大学;北京体育大学;国家体育总局运动医学研究所;集美大学;
【基金】：国家“十二五”科技支撑计划课题(2012BAK21B02) 国家自然科学基金(31401017) 教育部优秀博士论文课题(V200801)
【分类号】：R87

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