同步辐射衍射增强成像技术应用于小鼠肾脏的成像实验

发布时间：2018-07-01 09:12

本文选题：同步辐射 + 相位衬度　；参考：《中国医学计算机成像杂志》2016年04期

【摘要】：目的:不同于常规的吸收成像,相位衬度成像可以获得更高的衬度分辨率、显示更多的微细结构信息,尤其适合于轻元素(含氮、氢成分较高的组织)显示,本实验通过对小鼠肾脏组织的成像研究,旨在评价应用同步辐射相位衬度成像技术在软组织成像诊断上的价值。方法:在北京同步辐射装置形貌站4W1A束线上,设计衍射增强成像实验(DEI)光路,取经过福尔马林固定后的小鼠肾脏组织样品(根据光斑尺寸做适度切除),置于光路的样品架上进行成像,以空间分辨率和组织衬度作为评价标准。结果:在衍射增强(DEI)中腰位成像获得较好的对比度及图像衬度,可以显示包括肾小球结构在内的肾脏微细结构;采用333Si分析晶体要比111Si衬度明显提高。结论:衍射增强成像技术能较好显示肾脏的微细解剖结构,对于以轻元素为主的脏器成像有较好的应用价值,而对于适龄和老龄的肾脏之间存在着的血管模式、形态上的差异在某种程度上有一定的诊断价值。
[Abstract]:Objective: unlike conventional absorption imaging, phase contrast imaging can achieve higher contrast resolution and display more microstructural information, especially for light elements (tissues with high nitrogen and hydrogen content). The purpose of this study was to evaluate the value of synchrotron radiation phase contrast imaging in the diagnosis of soft tissue imaging. Methods: at the 4W1A beam line of the Beijing Synchrotron radiation Facility, a diffraction enhanced imaging (Dei) optical path was designed. After formalin fixation, the renal tissue samples of mice (resected moderately according to the size of light spots) were placed on the frame of the light path for imaging. The spatial resolution and tissue contrast were used as the evaluation criteria. Results: the contrast and contrast of lumbar images were obtained in diffractive contrast enhancement (DEI), and the renal microstructures, including glomerular structure, were revealed, and the contrast of crystal with 333Si was significantly higher than that of 111Si. Conclusion: diffraction enhanced imaging can better display the fine anatomy of kidney, and has good application value for visceral imaging with light elements, but there is a vascular pattern between the aged and the aged kidney. Morphological differences have some diagnostic value to some extent.
【作者单位】：上海市普陀区中心医院放射科;中国科学院北京高能物理研究所同步辐射实验室;
【基金】：上海市自然科学基金No:11ZR1427800~~
【分类号】：O434.1;R811

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