不同剂量计算网格对Ⅰ期非小细胞肺癌立体定向放射治疗剂量的影响

发布时间：2018-07-12 13:10

本文选题：非小细胞肺癌 + 体部立体定向放射治疗　；参考：《广东医学》2017年06期

【摘要】：目的比较不同剂量计算网格(CGS)在Ⅰ期非小细胞肺癌(NSCLC)立体定向治疗(SBRT)计划中的剂量学差异。方法选取10例NSCLC患者的SBRT计划,分别使用两种不同CGS(2.5 mm和1 mm),在相同射野角度和优化条件下分别进行计划设计并比较其剂量学差异。靶区根据密度不同分为在正常肺组织部分的计划靶区(PTV_lung)和在实体肿瘤部分的计划靶区(PTV_soft)。比较参数包括靶区的最低剂量(D_(min))、最高剂量(D_(max))、平均剂量(Dmean)和各危及器官剂量。结果 1 mm CGS组PTV_lung的D_(min)、D_(max)、D_(mean)和PTV_soft的D_(max)均明显高于2.5 mm CGS组,且PTV_lung的D_(mean)增加约1 Gy;在危及器官剂量方面,1 mm CGS组气管树、胸壁、脊髓、食管和患侧肺剂量均高于2.5 mm CGS组,以上差异均有统计学意义(P0.05)。结论在肺癌SBRT治疗中,采用1 mm CGS能改善剂量计算准确性并能提高靶区在正常肺组织部分的剂量。
[Abstract]:Objective to compare the dosimetric differences of different dose computational meshes (CGS) in the stereotactic therapy (SBRT) of stage I non-small cell lung cancer (NSCLC). Methods the SBRT plan of 10 patients with NSCLC was selected. Two different CGS (2.5 mm and 1 mm),) were used to design and compare the dosimetric differences under the same field angle and optimized conditions. The target area is divided into two groups according to the density: the planned target (PTV) in the normal lung tissue and the planning target (PTV) in the solid tumor. The comparison parameters include the lowest dose (D- (min), maximum dose) of target area (D- (max), mean dose) and the dose of each organ at risk. Results in the 1 mm CGS group, the D _ (min) D _ (max) D _ (mean) and the D _ (max) of the two groups were significantly higher than those in the 2.5 mm CGS group, and the D _ (mean) of PTV _ S was increased by about 1 Gy, and the dose of trachea tree, chest wall, spinal cord, esophagus and affected lung was higher than that of 2.5 mm CGS group in terms of the dose of organ in the 1 mm CGS group, and the dose of the lung in the esophagus and the affected side was higher than that in the 2. 5 mm CGS group. The above differences were statistically significant (P0.05). Conclusion in SBRT treatment of lung cancer, 1 mm CGS can improve the accuracy of dose calculation and the dose of target area in normal lung tissue.
【作者单位】：汕头大学医学院附属肿瘤医院放疗科;
【分类号】：R734.2;R730.55

【相似文献】