MSCT肾动脉成像优化碘对比剂剂量及浓度的动物实验研究
发布时间：2018-07-17 16:01
【摘要】：目的 通过三种不同浓度的非离子型单体碘对比剂，分别行高、中、低三种剂量多层螺旋CT犬肾动脉成像，探讨低浓度低剂量对比剂在犬肾动脉成像的可行性，为将低浓度低剂量碘对比剂应用于临床肾动脉CTA成像提供实验依据。 材料与方法 将不同浓度的碘对比剂分成三组（A-370mgI/ml, B-350mgI/ml,C-300mgI/ml）分别进行高、中、低三种剂量(1-2.40ml/kg,2-2.02ml/kg,3-1.62ml/kg)注射，共分为9组（A1-3、B1-3、C1-3）；对6只健康家犬以随机原则进行MSCT肾动脉成像扫描分析，每组进行8次扫描，合计72次。扫描完成后，将重建数据在工作站进行图像后处理。 两名副主任以上放射科医师，根据对原始图像以及后处理图像的容积重现（VR）、最大密度投影（MIP）、多平面重建（MPR）和曲面重建（CPR）图像，对犬肾动脉血管边缘情况、血管分支显影情况及肾实质显影情况进行评分。并分别在肾动脉主干分叉层面、主干背侧分支分叉层面、主干腹侧分支分叉层面、肾段动脉分支分叉层面、叶间动脉分支分叉层面共五个层面进行CT值测量，每组取各层面CT值均值进行统计学分析。 结果 1、两名副主任以上医师对犬肾动脉边缘显影情况、分支显影情况及肾实质显影情况的评分结果具有高度一致性，其Kappa值分别为0.781、0.773、0.783。 2、九组（A1、A2、A3、B1、B2、B3、C1、C2、C3）犬肾动脉边缘显影的评分结果依次为2.73±0.31、2.75±0.30、2.69±0.32、2.82±0.39、2.71±0.28、2.68±0.30、2.75±0.35、2.66±0.29、2.77±0.40；犬肾动脉分支显影的评分结果依次为3.73±0.36、3.81±0.42、3.69±0.35、3.71±0.46、3.65±0.50、3.70±0.43、3.77±0.41、3.86±0.41、3.74±0.53；犬肾实质评分结果依次为2.75±0.32、2.63±0.28、2.86±0.29、2.75±0.38、2.75±0.27、2.87±.031、2.63±0.51、2.63±0.42、2.75±0.50。各组图像动脉边缘情况、分支显影情况及肾实质显影情况组间两两比较均无显著性差异（P0.05）。 3、犬肾动脉不同分支血管内的CT值测量结果显示，A1、A2、A3；B1、B2、B3；C1、C2、C3各组组间两两比较具有显著性差异（P0.05）；A1、B1、C1；A2、B2、C2；A3、B3、C3各组组间两两比较无显著性差异（P0.05）。 结论 应用低浓度低剂量碘对比剂进行MSCT犬肾动脉CTA成像扫描，可以得到肾动脉的优质图像，为将低浓度低剂量碘对比剂应用于临床肾动脉CTA成像奠定了基础。
[Abstract]:Objective to evaluate the feasibility of three different concentrations of Nonionic iodide contrast agents in canine renal artery imaging with high, medium and low doses of multi-slice spiral CT. To provide experimental evidence for the application of low concentration and low dose iodine contrast agent in renal artery CTA imaging. Materials and methods different concentrations of iodine contrast agents were divided into three groups (A-370mgI / ml, B-350mgIml-1 / ml, C-300mgIr / ml) and injected with high, middle and low doses (1-2.40ml / kg2-2.02ml / kg / kg 3-1.62ml / kg), and were divided into 9 groups (A1-3Mg-B1-3C1-3). Each group was scanned 8 times, total 72 times. After the scan is completed, the reconstructed data is processed on the workstation. According to the volume rendering (VR), maximum density projection (MIP), multiplanar reconstruction (MPR) and curved surface reconstruction (CPR) of the original and post-processed images, two radiologists or above were used to evaluate the edge of the renal artery in canine renal artery, according to the volume rendering (VR), maximum intensity projection (MIP), multiplanar reconstruction (MPR) and curved surface reconstruction (CPR). The development of vascular branches and renal parenchyma were evaluated. The CT values were measured on five layers: the main branch of the renal artery, the dorsal branch of the main trunk, the ventral branch of the main trunk, the branch of the renal segment and the interlobar artery. The CT values of each group were statistically analyzed. Results 1. There was a high consistency among the scores of the edge of renal artery, branch development and renal parenchyma of two or more deputy chief physicians. 鍏禟appa鍊煎垎鍒负0.781,0.773,0.783. 2,涔濈粍(A1,A2,A3,B1,B2,B3,C1,C2,C3)鐘偩鍔ㄨ剦杈圭紭鏄惧奖鐨勮瘎鍒嗙粨鏋滀緷娆′负2.73卤0.31,2.75卤0.30,2.69卤0.32,2.82卤0.39,2.71卤0.28,2.68卤0.30,2.75卤0.35,2.66卤0.29,2.77卤0.40锛涚姮鑲惧姩鑴夊垎鏀樉褰辩殑璇勫垎缁撴灉渚濇涓，
本文编号：2130180
[Abstract]:Objective to evaluate the feasibility of three different concentrations of Nonionic iodide contrast agents in canine renal artery imaging with high, medium and low doses of multi-slice spiral CT. To provide experimental evidence for the application of low concentration and low dose iodine contrast agent in renal artery CTA imaging. Materials and methods different concentrations of iodine contrast agents were divided into three groups (A-370mgI / ml, B-350mgIml-1 / ml, C-300mgIr / ml) and injected with high, middle and low doses (1-2.40ml / kg2-2.02ml / kg / kg 3-1.62ml / kg), and were divided into 9 groups (A1-3Mg-B1-3C1-3). Each group was scanned 8 times, total 72 times. After the scan is completed, the reconstructed data is processed on the workstation. According to the volume rendering (VR), maximum density projection (MIP), multiplanar reconstruction (MPR) and curved surface reconstruction (CPR) of the original and post-processed images, two radiologists or above were used to evaluate the edge of the renal artery in canine renal artery, according to the volume rendering (VR), maximum intensity projection (MIP), multiplanar reconstruction (MPR) and curved surface reconstruction (CPR). The development of vascular branches and renal parenchyma were evaluated. The CT values were measured on five layers: the main branch of the renal artery, the dorsal branch of the main trunk, the ventral branch of the main trunk, the branch of the renal segment and the interlobar artery. The CT values of each group were statistically analyzed. Results 1. There was a high consistency among the scores of the edge of renal artery, branch development and renal parenchyma of two or more deputy chief physicians. 鍏禟appa鍊煎垎鍒负0.781,0.773,0.783. 2,涔濈粍(A1,A2,A3,B1,B2,B3,C1,C2,C3)鐘偩鍔ㄨ剦杈圭紭鏄惧奖鐨勮瘎鍒嗙粨鏋滀緷娆′负2.73卤0.31,2.75卤0.30,2.69卤0.32,2.82卤0.39,2.71卤0.28,2.68卤0.30,2.75卤0.35,2.66卤0.29,2.77卤0.40锛涚姮鑲惧姩鑴夊垎鏀樉褰辩殑璇勫垎缁撴灉渚濇涓，
本文编号：2130180
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