倍增时间在磨玻璃结节随访中的应用价值

发布时间：2018-07-27 10:33

【摘要】：目的探讨肿瘤倍增时间(DT)在肺内磨玻璃结节(GGNs)中的应用价值。方法回顾性分析2008年9月至2015年12月在华东医院诊治的78例肺内GGNs的影像学资料,结节均经手术切除,术后病理证实为微浸润性腺癌(MIA)和浸润性腺癌(IAC)。根据密度差异将初诊结节分为纯磨玻璃结节(pGGN)及混合性磨玻璃结节(mGGN),采用体积倍增时间(VDT)计算,不同类型结节的DT具有统计学差异。结果 78例GGNs中共有pGGN40例,mGGN 38例,术后病理:MIA 38例,IAC 40例。pGGN的平均DT为845天,mGGN的平均DT为538天,使用独立样本t检验,两者差异具有统计学意义(P0.05)。设定DT≤730天、1095天、1460天,分别作为MIA和IAC的诊断阈值,pGGN诊断为MIA敏感性分别为67%、78%、73%,特异性33%、50%、29%,准确性50%、60%、56%。设定DT≤365天、730天、1095天,分别作为MIA和IAC的诊断阈值,mGGN诊断为MIA敏感性分别为25%、27%、24%,特异性50%、88%、89%,准确性33%、59%、58%。结论 mGGN较pGGN增长快速,随访中应缩短随访间隔及随访时间;初诊为pGGN时,以DT≤1095天作为手术点有较高的价值;初诊为mGGN时,以DT≤730天作为手术点有较高的价值。
[Abstract]:Objective to evaluate the value of tumor doubling time (DT) in (GGNs) of intrapulmonary milled glass nodules. Methods from September 2008 to December 2015, the imaging data of 78 cases of pulmonary GGNs in East China Hospital were retrospectively analyzed. The nodules were surgically resected and pathologically proved to be microinvasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC). According to the density difference, the newly diagnosed nodules were divided into pure ground glass nodules (pGGN) and mixed ground glass nodules (mGGN),) by volume doubling time (VDT). The DT of different types of nodules was statistically different. Results there were 38 cases of pGGN40 in 78 cases of GGNs. The mean DT of 40 cases was 845 days and the average DT of PGGN was 538 days. The difference between them was statistically significant (P0.05). Setting DT 鈮，

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