ER和PR同一表达状态下HER-2与乳腺癌X线表现的相关性分析

发布时间：2018-08-09 19:25

【摘要】：目的探讨乳腺癌免疫组织化学中雌激素受体(ER)和孕激素受体(PR)表达一致条件下,人类表皮生长因子受体2(HER-2)的表达状态和乳腺癌X线表现之间的相关性。方法回顾性分析经手术病理确诊的1533例女性乳腺癌患者的X线表现,根据免疫组织化学(IHC)中HER-2、ER、PR的表达结果分为Ⅰa(HER-2阳性/ER-/PR-)和Ⅰb(HER-2阴性/ER-/PR-)、Ⅱa(HER-2阳性/ER+/PR+)和Ⅱb(HER-2阴性/ER+/PR+)两个配对组。分别对两个配对组中乳腺癌的肿块和钙化进行分析,并对各项分析结果进行统计学检验。结果Ⅰa和Ⅰb组中,HER-2表达阳性乳腺癌多见单纯钙化(18.3%)、肿块伴钙化(23.7%),HER-2表达阴性乳腺癌单纯肿块比较多见(49.2%);HER-2表达阳性乳腺癌肿块形态以不规则形多见(47.4%),HER-2表达阴性乳腺癌肿块以类圆形(58.8%)、分叶状(12.1%)多见;HER-2表达阳性乳腺癌肿块边界多模糊不清(86.1%),HER-2表达阴性乳腺癌肿块边界多清楚局限(9.8%)。与HER-2表达阳性乳腺癌比较,阴性乳腺癌砂砾状钙化(55.2%)多见,且大多呈区域性分布(32.1%)。Ⅱa和Ⅱb组中,HER-2表达阳性乳腺癌类圆形(52.1%)、分叶状肿块(11.0%)多见,HER-2表达阴性乳腺癌不规则形肿块(40.6%)多见;HER-2表达阳性乳腺癌肿块边界多模糊不清(90.7%),大多可见毛刺边缘(66.7%),HER-2表达阴性乳腺癌肿块边缘多见浅分叶(65.3%)。与HER-2表达阴性乳腺癌比较,阳性乳腺癌砂砾状钙化(68.4%)多见,且大多呈节段性分布(31.9%),HER-2表达阴性乳腺癌钙化大多成簇状分布(57.6%)。结论各配对组中HER-2表达阳性与阴性乳腺癌的肿块及钙化有着不同的X线表现。
[Abstract]:Objective to investigate the correlation between the expression of human epidermal growth factor receptor 2 (HER-2) and the X-ray findings of breast cancer under the condition of consistent expression of estrogen receptor (ER) and progesterone receptor (PR) in breast cancer. Methods the X-ray findings of 1533 cases of female breast cancer confirmed by operation and pathology were analyzed retrospectively. According to the expression of HER-2ER-PR in immunohistochemical (IHC), HER-2ER-PR was divided into two matched groups: 鈪，

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