运动后氧化应激水平及合理补充抗氧化剂的科学评价方法

发布时间：2018-09-07 08:30

【摘要】：背景:人体在大强度运动过程中,体内自由基大量产生和蓄积是导致运动性疲劳和运动损伤的重要因素,而外源性抗氧化剂的摄入可以增强机体的运动和抗氧化能力。目前针对运动过程中及运动后抗氧化剂的合理补充方式尚缺乏有效的指导和研究。目的:对运动氧化应激水平及合理补充抗氧化剂效果的评定方法进行分析和探讨。方法:检索ScienceDirect数据库相关文献,关键词为"运动;氧化应激损伤;抗氧化剂;线粒体",对纳入的有关国内外运动性氧化应激损伤及抗氧化剂补充干预的文献进行整理分析。结果与结论:运动训练可以使机体抗氧化应激能力增强,同时潜在的氧化损伤风险也会随之积累。合理的抗氧化剂补充对于提高体内抗氧化能力,延缓氧化应激反应及其所导致氧化系统及抗氧化系统的失衡引起机体的细胞结构和功能损伤具有显著作用。而抗氧化剂补充的方式、总量以及补充的时间节点是影响大强度运动后氧化应激损伤和运动能力适应性变化的关键因素。体液中DNA氧化损伤生物标记物8-OHdG等指标变化可作为评价运动氧化应激反应及运动适应性恢复状态和抗氧化剂补充作用的重要参考指标。
[Abstract]:Background: during high intensity exercise, the production and accumulation of free radicals in human body is an important factor leading to exercise fatigue and exercise injury, and the intake of exogenous antioxidants can enhance the exercise and antioxidant ability of the body. At present, there is a lack of effective guidance and research on the reasonable supplement of antioxidants during and after exercise. Objective: to analyze the level of exercise oxidative stress and evaluate the effect of supplementation of antioxidants. Methods: to search the relevant literatures of ScienceDirect database, the key words were "exercise; oxidative stress injury; antioxidant; mitochondria". Results & conclusion: exercise training can increase the ability of antioxidant stress and the potential risk of oxidative damage. Reasonable supplementation of antioxidants plays a significant role in enhancing antioxidant capacity in vivo, delaying oxidative stress response and the imbalance of oxidation system and antioxidant system, which results in cell structure and function damage. However, the way of antioxidant supplement, the total amount and the time node of supplement are the key factors that affect the oxidative stress injury and the adaptability of exercise ability after heavy intensity exercise. The changes of 8-OHdG, a biomarker of DNA oxidative damage in body fluid, can be used as important reference indexes for evaluating oxidative stress response, fitness recovery and antioxidant supplementation.
【作者单位】：广州中医药大学热带医学研究所;广东省体育科学研究所;广东药科大学附属第一医院;广州体育学院;
【基金】：广东省体育专项科研资金资助项目(GDSS2016155) 广东省医学科研基金资助项目(A2016600)~~
【分类号】：R87

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