特殊营养制剂对模拟飞行环境下大鼠排便及相关功能的影响
发布时间：2018-10-08 18:20
【摘要】：目的:观察特殊营养制剂对模拟飞行环境下SD大鼠热能摄入、排便情况、血糖及耐力的影响,探讨该营养制剂对飞行环境下大鼠生存指标的影响,为后续实验及该营养制剂在飞行员餐食中的推广使用提供有效的数据支持。方法:40只SD大鼠随机分为两组,20只为普通饲料组(Normal diet,ND组),普通饲料喂养;20只为营养制剂组(Intervention diet,ID组),特殊营养制剂喂养;实验历时72h,每组大鼠分笼饲养、模拟飞行环境暴露,记录每笼大鼠摄食、排便情况。结果:1.ID组大鼠干预期间与干预前相比,大鼠6h湿粪便质量(P0.05)、干粪便质量(P0.05)、粪便含水率(P0.05)具有显著性差异,其中,该组大鼠6h平均湿粪便质量、平均干粪便质量均较干预前的低,粪便平均含水率较干预前高;2.ID组首次排便时间(115.0±42.13)min较ND组(123.0±37.68)min短,但并无统计学意义(P0.05);干预前,两组大鼠6h湿粪便质量(P0.05)、干粪便质量(P0.05)、粪便含水率(P0.05)无显著性差异;干预期间,ID组与ND组相比,大鼠6h湿粪便质量(P0.05)、干粪便质量(P0.05)具有显著性差异;其中,ID组大鼠6h平均湿粪便质量、平均干粪便质量均较ND组低,粪便平均含水率(P0.05)无显著性差异;3.ND组大鼠在干预期间与干预前相比,大鼠6h湿粪便质量(P0.05)、干粪便质量(P0.05)、粪便含水率(P0.05);其中干预期前6h平均干粪便质量、粪便含水率较干预期前的低,6h湿粪便质量差异无显著性;4.干预期间ID组大鼠血糖值(5.19±0.64)mmol/L较ND组(5.39±0.66)mmol/L低(P0.05),大鼠各时段血糖值均在95%正常范围内;两组大鼠负重游泳存活时间差异无统计学意义(P0.05);5.两组大鼠各生化指标方差齐性(P0.05)相同,且两组大鼠干预结束后,各生化指标均在正常范围内,两组间差异无统计学意义。结论:根据飞行员膳食特点设计的特殊营养制剂具有显著抑制大鼠排便量,同时不会影响大鼠血糖、耐力的功效,其具体作用机制及现场人体试验效果验证有待进一步开展。同时,模拟飞行环境下大鼠由于受到高角加速度、高空环境的影响,粪便性状发生了改变,肠道及粪便菌群失调有待下一阶段实验验证。
[Abstract]:Objective: to observe the effects of special nutrition preparation on the intake of heat energy, defecation, blood glucose and endurance of SD rats in simulated flying environment, and to explore the effects of the preparation on the survival index of rats in flight environment. To provide effective data support for the follow-up experiment and the popularization and use of the nutritional preparation in the pilots' meals. Methods 40 SD rats were randomly divided into two groups: normal diet group (Normal diet,ND group) and normal diet group (Intervention diet,ID group). The feeding and defecation of each cage rat were recorded. Results 1. There were significant differences in wet fecal mass (P0.05), dry fecal mass (P0.05) and fecal moisture content (P0.05) during the intervention period. The average wet fecal mass and the average dry fecal mass in the group were lower than those before the intervention. The mean fecal moisture content in group ID was (115.0 卤42.13) min shorter than that in group ND (123.0 卤37.68) min, but there was no significant difference between the two groups before intervention (P0.05) in wet fecal mass (P0.05), dry fecal mass (P0.05), and fecal moisture content (P0.05). During the intervention period, there were significant differences in wet fecal mass (P0.05) and dry fecal quality (P0.05) between the control group and the ND group, in which the average wet fecal mass and the average dry fecal mass of the rats in the control group were lower than those in the ND group. There was no significant difference in the average fecal moisture content (P0.05). During the intervention period, the wet fecal mass (P0.05), the dry fecal mass (P0.05), the fecal moisture content (P0.05) in ND group were compared with those before intervention. There was no significant difference in fecal moisture content between the two groups. During the intervention period, the blood glucose value of ID group (5.19 卤0.64) mmol/L was lower than that of ND group (5.39 卤0.66) mmol/L (P0.05), and the blood glucose value of rats in each period was in the range of 95% normal. There was no significant difference in survival time of weight-bearing swimming between the two groups (P0.05). The homogeneity of each biochemical index in the two groups was the same (P0.05), and after the intervention of the two groups, the biochemical indexes were all within the normal range, there was no significant difference between the two groups. Conclusion: the special nutritional preparation designed according to the dietary characteristics of pilots can significantly inhibit the defecation volume of rats without affecting the blood glucose and endurance of the rats. The specific mechanism of the preparation and the effect of field human experiments need to be further developed. At the same time, the fecal characteristics of the simulated flying environment were changed due to high angular acceleration and high altitude environment. The intestinal tract and faecal flora imbalance needed to be verified in the next stage of the experiment.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R85
[Abstract]:Objective: to observe the effects of special nutrition preparation on the intake of heat energy, defecation, blood glucose and endurance of SD rats in simulated flying environment, and to explore the effects of the preparation on the survival index of rats in flight environment. To provide effective data support for the follow-up experiment and the popularization and use of the nutritional preparation in the pilots' meals. Methods 40 SD rats were randomly divided into two groups: normal diet group (Normal diet,ND group) and normal diet group (Intervention diet,ID group). The feeding and defecation of each cage rat were recorded. Results 1. There were significant differences in wet fecal mass (P0.05), dry fecal mass (P0.05) and fecal moisture content (P0.05) during the intervention period. The average wet fecal mass and the average dry fecal mass in the group were lower than those before the intervention. The mean fecal moisture content in group ID was (115.0 卤42.13) min shorter than that in group ND (123.0 卤37.68) min, but there was no significant difference between the two groups before intervention (P0.05) in wet fecal mass (P0.05), dry fecal mass (P0.05), and fecal moisture content (P0.05). During the intervention period, there were significant differences in wet fecal mass (P0.05) and dry fecal quality (P0.05) between the control group and the ND group, in which the average wet fecal mass and the average dry fecal mass of the rats in the control group were lower than those in the ND group. There was no significant difference in the average fecal moisture content (P0.05). During the intervention period, the wet fecal mass (P0.05), the dry fecal mass (P0.05), the fecal moisture content (P0.05) in ND group were compared with those before intervention. There was no significant difference in fecal moisture content between the two groups. During the intervention period, the blood glucose value of ID group (5.19 卤0.64) mmol/L was lower than that of ND group (5.39 卤0.66) mmol/L (P0.05), and the blood glucose value of rats in each period was in the range of 95% normal. There was no significant difference in survival time of weight-bearing swimming between the two groups (P0.05). The homogeneity of each biochemical index in the two groups was the same (P0.05), and after the intervention of the two groups, the biochemical indexes were all within the normal range, there was no significant difference between the two groups. Conclusion: the special nutritional preparation designed according to the dietary characteristics of pilots can significantly inhibit the defecation volume of rats without affecting the blood glucose and endurance of the rats. The specific mechanism of the preparation and the effect of field human experiments need to be further developed. At the same time, the fecal characteristics of the simulated flying environment were changed due to high angular acceleration and high altitude environment. The intestinal tract and faecal flora imbalance needed to be verified in the next stage of the experiment.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R85
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