基于基质金属蛋白酶2、9调控细胞外基质稳态的离心训练干预2型糖尿病研究进展

发布时间：2018-10-10 07:45

【摘要】：骨骼肌胰岛素抵抗是2型糖尿病的主要病理性特征,但其发生机制仍不十分清楚。近来研究证实,炎症反应引起的细胞外基质(ECM)胶原纤维沉积导致骨骼肌胰岛素抵抗症状发生,原因与基质金属蛋白酶2、9(MMP-2、9)表达失调有关。鉴于骨骼肌是胰岛素作用的主要靶点,能最大程度吸收和利用脂肪、葡萄糖转运供能,普遍认为运动是预防或治疗2型糖尿病的较好干预措施之一。然而,2型糖尿病患者通常伴有小血管和大血管疾病并发症,进行剧烈运动时很容易出现心血管负荷过载的风险。因此,在具备调控骨骼肌基质金属蛋白酶家族(MMPs)表达量,改善骨骼肌细胞外基质微环境的前提条件下,探讨既可以提高骨骼肌胰岛素敏感性又不诱发心血管负荷过载风险的运动方式具有非常重要的实践意义。本文探讨离心训练干预2型糖尿病的可行性及其运动风险预防优势。结果表明,离心训练能有效增加骨骼肌毛细血管密度、脂肪和葡萄糖代谢量,可能与离心训练通过调控MMP-2、9表达进而改善骨骼肌细胞外基质微环境有关,且由于离心训练时募集的运动单位较少,可以降低运动造成的心血管负荷过载的风险。离心训练干预对2型糖尿病尤其是2型糖尿病血管并发症患者具有独特的降低运动风险的优势。
[Abstract]:Insulin resistance in skeletal muscle is the main pathological feature of type 2 diabetes, but its mechanism is still unclear. Recent studies have demonstrated that the deposition of extracellular matrix (ECM) collagen fibers induced by inflammation may lead to insulin resistance in skeletal muscle, which is related to the imbalance of matrix metalloproteinase-2 (MMP-2,9) expression. Since skeletal muscle is the main target of insulin, which can absorb and utilize fat to the maximum extent, glucose transport energy, it is generally considered that exercise is one of the better intervention measures to prevent or treat type 2 diabetes. However, patients with type 2 diabetes are often associated with complications of microvascular and macrovascular diseases, and risk of cardiovascular overload during strenuous exercise. Therefore, under the precondition of regulating the expression of matrix metalloproteinase (MMPs) in skeletal muscle and improving the extracellular matrix microenvironment of skeletal muscle, It is of great practical significance to explore the exercise mode which can improve the insulin sensitivity of skeletal muscle and do not induce cardiovascular overload risk. This paper discusses the feasibility of centrifugal training in type 2 diabetes mellitus and the advantages of exercise risk prevention. The results showed that centrifugal training could effectively increase the density of capillaries and metabolism of fat and glucose in skeletal muscle, which might be related to the improvement of extracellular matrix microenvironment of skeletal muscle by regulating the expression of MMP-2,9 in centrifuge training. In addition, the risk of cardiovascular overload caused by exercise can be reduced because of the small number of sports units recruited during centrifugal training. Centrifugal training intervention has a unique advantage in reducing exercise risk in patients with type 2 diabetes, especially in patients with vascular complications of type 2 diabetes.
【作者单位】：曲阜师范大学体育科学学院;
【基金】：山东省自然科学基金面上项目(编号:ZR2014CL015)
【分类号】：R87

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