CEUS观察兔肝VX2肿瘤坏死演变
发布时间：2018-10-13 09:54
【摘要】：目的应用CEUS技术观察兔肝VX2肿瘤坏死过程,探讨VX2肿瘤生长坏死规律及其对实验产生的影响。方法应用超声引导下经皮穿刺种植法成功建立24只兔VX2肝肿瘤模型,并通过CEUS技术分别在肿瘤种植后10、14、21、28天动态观察肝肿瘤演变过程,测量肿瘤体积及坏死体积,计算瘤内坏死率。结果在肿瘤种植后10、14、21、28天兔肝VX2肿瘤体积、坏死灶体积和坏死率比较,差异均有统计学意义(P均0.05);肿瘤种植后10、14、21、28天的CEUS表现能反映出肿瘤的病理学特征。实验依据CEUS和病理特点将肿瘤生长过程细分为5个时期,0~10天为肿瘤实质前期;11~14天为肿瘤实质后期;15~21天为肿瘤坏死初期;22~28天为加速坏死期;28天后为肿瘤囊变期。结论 CEUS可准确判断肝肿瘤实质及坏死范围;VX2肿瘤的生长演变及肿瘤坏死具有规律性,可根据不同实验要求选择适宜的研究时间段。
[Abstract]:Objective to observe the process of VX2 tumor necrosis in rabbit liver by CEUS technique and to explore the law of VX2 tumor growth and necrosis and its effect on the experiment. Methods 24 VX2 liver tumor models were successfully established by ultrasound guided percutaneous puncture implantation. The tumor evolution was observed by CEUS technique at 10 ~ 1414 ~ 21 ~ (-1) days after implantation, and tumor volume and necrotic volume were measured. The rate of necrosis in tumor was calculated. Results there were significant differences in tumor volume, necrotic focus volume and necrosis rate between rabbits with VX2 on the 10th day after implantation of the tumor (P 0.05), and the CEUS findings of 10 ~ 14 ~ 21 ~ 28 days after implantation could reflect the pathological features of the tumor. According to the characteristics of CEUS and pathology, the tumor growth process was subdivided into 5 stages, 10 days were precancerous stage, 1114 days were late stage of tumor parenchyma, 15 days were early stage of tumor necrosis, 2228 days were accelerated necrotic phase, and 28 days later were cystic phase of tumor. Conclusion CEUS can accurately judge the parenchyma and necrotic range of liver tumors, and the growth and necrosis of VX2 tumors are regular, and the appropriate time period can be selected according to different experimental requirements.
【作者单位】： 西安交通大学第一附属医院超声科;西安市第一医院超声科;
【基金】：国家自然科学基金(81171355)
【分类号】：R735.7;R730.44;R445.1
[Abstract]:Objective to observe the process of VX2 tumor necrosis in rabbit liver by CEUS technique and to explore the law of VX2 tumor growth and necrosis and its effect on the experiment. Methods 24 VX2 liver tumor models were successfully established by ultrasound guided percutaneous puncture implantation. The tumor evolution was observed by CEUS technique at 10 ~ 1414 ~ 21 ~ (-1) days after implantation, and tumor volume and necrotic volume were measured. The rate of necrosis in tumor was calculated. Results there were significant differences in tumor volume, necrotic focus volume and necrosis rate between rabbits with VX2 on the 10th day after implantation of the tumor (P 0.05), and the CEUS findings of 10 ~ 14 ~ 21 ~ 28 days after implantation could reflect the pathological features of the tumor. According to the characteristics of CEUS and pathology, the tumor growth process was subdivided into 5 stages, 10 days were precancerous stage, 1114 days were late stage of tumor parenchyma, 15 days were early stage of tumor necrosis, 2228 days were accelerated necrotic phase, and 28 days later were cystic phase of tumor. Conclusion CEUS can accurately judge the parenchyma and necrotic range of liver tumors, and the growth and necrosis of VX2 tumors are regular, and the appropriate time period can be selected according to different experimental requirements.
【作者单位】： 西安交通大学第一附属医院超声科;西安市第一医院超声科;
【基金】：国家自然科学基金(81171355)
【分类号】：R735.7;R730.44;R445.1
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