基于CTA和眼底成像观察颈内动脉狭窄程度与视网膜血管管径的关系
发布时间：2018-10-25 10:37
【摘要】：目的分析颈内动脉(ICA)狭窄程度与同侧视网膜血管管径的关系,探讨通过观察视网膜血管管径改变评估ICA狭窄的准确性及可行性。方法基于CTA和眼底成像技术,分析243例患者单侧ICA狭窄程度和同侧视网膜血管管径资料,根据ICA最大狭窄率(Rmax)将患者分为无狭窄、轻度狭窄、中度狭窄和重度狭窄共4组,分析视网膜血管管径的组间差异及其与ICA狭窄程度的相关性。结果中、重度狭窄组的视网膜中央静脉管径(CRVE)较无狭窄和轻度狭窄组明显增宽(P均0.05),4组间视网膜中央动脉管径(CRAE)和动静脉管径比值(AVR)差异无统计学意义(P均0.05)。Rmax与同侧CRVE呈正相关(r=0.27,P0.01),与AVR呈负相关(r=-0.16,P0.05),与CRAE无相关性(P0.05)。CRVE是同侧Rmax的影响因素(B=0.243,P0.01),但模型的调整R2较小(0.173)。以229.5μm为最佳临界值,CRVE诊断ICA中重度狭窄的ROC曲线下面积为0.619,敏感度和特异度为80.3%、40.1%。结论 CRVE对ICA狭窄程度的评估与预测具有一定价值。
[Abstract]:Objective to analyze the relationship between the degree of (ICA) stenosis of internal carotid artery and the diameter of ipsilateral retinal vessels, and to explore the accuracy and feasibility of evaluating ICA stenosis by observing the changes of retinal vascular diameter. Methods based on CTA and fundus imaging, the data of unilateral ICA stenosis and ipsilateral retinal vascular diameter in 243 patients were analyzed. According to the maximum stenosis rate of ICA, the patients were divided into 4 groups: no stenosis, mild stenosis, moderate stenosis and severe stenosis. To analyze the difference of retinal vascular diameter and its correlation with the degree of ICA stenosis. As a result, The diameter of central retinal vein (CRVE) in severe stenosis group was significantly wider than that in non-stenosis group and mild stenosis group (P0. 05). There was no significant difference in (CRAE) and (AVR) ratio between 4 groups (P 0. 05). Rmax vs ipsilateral CRVE). Positive correlation (r = 0.27, P 0.01), negative correlation with AVR (r = 0.16, P 0.05), no correlation with CRAE (P0.05,). CRVE was an influential factor of ipsilateral Rmax (P 0.05, P 0.01), but the adjusted R2 of the model was smaller (0.173). With 229.5 渭 m as the best critical value, the area under the ROC curve of CRVE for the diagnosis of moderate and severe stenosis of ICA was 0.619, and the sensitivity and specificity were 80.3% and 40.1% respectively. Conclusion CRVE is valuable in the evaluation and prediction of ICA stenosis.
【作者单位】： 首都医科大学附属北京友谊医院放射科;首都医科大学附属北京友谊医院眼科;
【基金】：北京市医院管理局临床技术创新项目(XMLX201305) “使命”人才计划(SML20150101) 北京学者(京人社专家发[2015]160号) 科技北京百名领军人才培养工程(Z141107001514002)
【分类号】：R816.97
[Abstract]:Objective to analyze the relationship between the degree of (ICA) stenosis of internal carotid artery and the diameter of ipsilateral retinal vessels, and to explore the accuracy and feasibility of evaluating ICA stenosis by observing the changes of retinal vascular diameter. Methods based on CTA and fundus imaging, the data of unilateral ICA stenosis and ipsilateral retinal vascular diameter in 243 patients were analyzed. According to the maximum stenosis rate of ICA, the patients were divided into 4 groups: no stenosis, mild stenosis, moderate stenosis and severe stenosis. To analyze the difference of retinal vascular diameter and its correlation with the degree of ICA stenosis. As a result, The diameter of central retinal vein (CRVE) in severe stenosis group was significantly wider than that in non-stenosis group and mild stenosis group (P0. 05). There was no significant difference in (CRAE) and (AVR) ratio between 4 groups (P 0. 05). Rmax vs ipsilateral CRVE). Positive correlation (r = 0.27, P 0.01), negative correlation with AVR (r = 0.16, P 0.05), no correlation with CRAE (P0.05,). CRVE was an influential factor of ipsilateral Rmax (P 0.05, P 0.01), but the adjusted R2 of the model was smaller (0.173). With 229.5 渭 m as the best critical value, the area under the ROC curve of CRVE for the diagnosis of moderate and severe stenosis of ICA was 0.619, and the sensitivity and specificity were 80.3% and 40.1% respectively. Conclusion CRVE is valuable in the evaluation and prediction of ICA stenosis.
【作者单位】： 首都医科大学附属北京友谊医院放射科;首都医科大学附属北京友谊医院眼科;
【基金】：北京市医院管理局临床技术创新项目(XMLX201305) “使命”人才计划(SML20150101) 北京学者(京人社专家发[2015]160号) 科技北京百名领军人才培养工程(Z141107001514002)
【分类号】：R816.97
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