重组乙肝疫苗在部队人群中免疫效果观察

发布时间：2018-11-07 19:46

【摘要】：目的调查军队人群乙肝血清抗体的本底水平,观察重组乙肝疫苗(20μg/ml)的免疫效果,为探索适合新兵、新学员的乙肝免疫程序打下基础。方法通过血清抗体初筛确定10 102名新兵为观察对象,免疫前抗-HBs检测结果为弱阳性者按照0、1程序接种2针乙肝疫苗,分别在2针后测抗-HBs水平;免疫前抗-HBs检测结果为阴性者按照0、1、6程序接种3针乙肝疫苗,分别在第2、3针后测抗-HBs水平;比较不同针次后的抗-HBs阳转率、抗体几何平均滴度(GMT)水平,阴性者的高应答反应。结果免疫前10 102名观察对象的血清抗-HBs检测中弱阳性者为1090人(10.8%),阴性者为3251人(32.2%)。弱阳性者接种乙肝疫苗1、2针后阳转率分别为90.0%、97.8%,GMT分别为5007.75 m IU/ml和6295.77 m IU/ml;接种2针阳转率明显优于接种1针(P0.01)。阴性者接种乙肝疫苗2、3针后采血,阳转率分别为86.1%、98.7%,高应答反应率分别为56.4%、87.5%,GMT分别为1214.41 m IU/ml和2231.57 m IU/ml;接种3针阳转率明显优于接种2针(P0.01)。本次试验期间,未收到三级(含)及以上不良反应报告。结论有必要在免疫前先进行抗-HBs检测,再选用重组乙肝疫苗(20μg/ml)进行科学接种;血清抗-HBs弱阳性对象选用0、1两针接种程序,血清抗-HBs阴性对象选用0、1、6三针接种程序,均可获得明显的免疫效果。
[Abstract]:Objective to investigate the background level of hepatitis B antibody in army population, and to observe the immune effect of recombinant hepatitis B vaccine (20 渭 g/ml) so as to lay a foundation for exploring the hepatitis B immunization program suitable for recruits and new cadets. Methods 10 102 recruits were screened by serum antibody. The results of anti-HBs test before immunization showed that the weakly positive persons were inoculated with 2 doses of hepatitis B vaccine according to the program of 0: 1, and the level of anti-HBs was measured after 2 doses. Three doses of hepatitis B vaccine were inoculated according to the procedure of 01 / 6, and the level of anti-HBs was measured after the second dose of 3 doses in the patients who were negative for anti-HBs test before and after immunization. The positive conversion rate of anti-HBs, the (GMT) level of geometric mean titer of antibody and the high response of negative patients were compared. Results 1090 (10.8%) cases were weakly positive and 3251 (32.2%) were negative in the detection of serum anti- HBs in 10 102 subjects before immunization. The positive conversion rates of the weakly positive patients inoculated with hepatitis B vaccine were 90.097.8 and 5007.75 m IU/ml and 6295.77 m IU/ml;, respectively, which were significantly better than that of the first dose (P0.01). The positive conversion rates were 86.1 and 98.7, respectively, and the high response rates were 56.4 and 87.5 IU/ml, respectively, and 2231.57 IU/ml; and 1214.41 m IU/ml, respectively, in the patients with negative hepatitis B vaccine. The positive conversion rate of 3 needles inoculated was significantly better than that of 2 needles inoculated (P0.01). During this trial, no adverse reactions were reported at level 3 (inclusive) or above. Conclusion it is necessary to detect anti-HBs before immunization and then select recombinant hepatitis B vaccine (20 渭 g/ml) for scientific inoculation. Two inoculation procedures were used for the weakly positive subjects with serum anti-HBs and three injections for the negative subjects with anti-HBs. The results showed that the immune effect was obvious.
【作者单位】：中央军委后勤保障部卫生局;解放军疾病预防控制所免疫规划中心;军事交通学院;军事经济学院襄阳士官学校;海军工程大学;空军勤务学院;武警部队学院;
【分类号】：R824.2

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