基于流固耦合的受载骨内溶质输运的有限元研究

发布时间：2018-12-09 19:53

【摘要】：骨骼是人体的重要器官,具有重要的生理功能。与其他组织相同,骨组织处在一个动态三维环境,其内部的流体及溶质运输对维持组织功能及本体活性具有不可替代的作用。目前光脱色荧光恢复技术(FRAP)是研究骨内流体及溶质运输的主要手段,但由于光学成像技术的局限性,只能针对骨膜以下50μm区域进行观察分析。本文从流固耦合理论和有限元法出发,对成年鼠胫骨进行有限元仿真研究,并结合FRAP实验验证有限元法应用于骨内流体及溶质运输研究的可行性。本文研究的主要内容及结论包括：(1)利用二维CT断层图像及Mimics软件平台,实现成年鼠胫骨的三维重建。在Hypermesh下对胫骨三维模型进行网格划分,三维重建后的网格模型与胫骨实物具有很高的相似度。(2)建立成年鼠胫骨的两相-溶质模型,获得包括弹性模量、孔隙度、渗透率在内的成年鼠胫骨模型相关参数。利用FEBio生物有限元仿真软件,获得了不同溶质扩散率以及载荷刺激下的骨陷窝-骨小管系统(LCS)内溶质输运特性。论述了输运增强度的概念,讨论了扩散率以及载荷对于输运增强度的影响。(3)结合成年鼠胫骨骨膜50μm以下区域的有限元分析及光脱色荧光恢复实验(FRAP)数据,讨论实验条件下载荷大小对于LCS系统内溶质输运现象的影响。比对同样载荷条件下两种方法得到的骨陷窝-骨小管系统内溶质输运增强度,验证生物有限元法在骨内流体以及溶质输运研究的可行性。(4)利用有限元法,进一步研究骨内深层区域流场分布信息,得到了不同载荷强度下胫骨表面以及横断面的流体压力、流体流量、溶质流量分布；并进一步探讨,孔隙度增大对于骨内LCS系统流动性影响。
[Abstract]:Bone is an important organ of human body and has important physiological function. Like other tissues, bone tissue is in a dynamic three-dimensional environment, and its internal fluid and solute transport plays an irreplaceable role in maintaining tissue function and bulk activity. At present, (FRAP) is the main method to study the transport of fluid and solute in bone. However, due to the limitation of optical imaging technology, only 50 渭 m below the periosteum can be observed and analyzed. Based on the fluid-solid coupling theory and finite element method, the finite element simulation of adult rat tibia is carried out, and the feasibility of applying the finite element method to the study of intraosseous fluid and solute transport is verified by FRAP experiment. The main contents and conclusions of this paper are as follows: (1) 3D reconstruction of adult rat tibia is realized by using two-dimensional CT tomography and Mimics software platform. The three-dimensional model of tibia was meshed by Hypermesh. The mesh model after 3D reconstruction had a high similarity with the tibia. (2) the two-phase solute model of adult rat tibia was established, which included elastic modulus and porosity. The related parameters of tibial model of adult rats included permeability. The transport characteristics of solute in bone lacunae bone tubule system (LCS) stimulated by different solute diffusivity and load were obtained by using FEBio biological finite element simulation software. The concept of transport enhancement is discussed, and the effects of diffusivity and load on transport enhancement are discussed. (3) combined with finite element analysis of tibial periosteum below 50 渭 m in adult rats and (FRAP) data of photochromic fluorescence recovery experiment, The effect of load on solute transport in LCS system is discussed. Comparing the enhancement degree of solute transport between the two methods under the same load conditions, the feasibility of the biological finite element method in the study of intraosseous fluid and solute transport is verified. (4) the finite element method is used to study the transport of solute in bone. The distribution of fluid pressure, fluid flow and solute flux on tibia surface and cross section under different loading intensity were obtained by further studying the distribution information of flow field in deep bone region. Furthermore, the effect of increased porosity on the flow of LCS system in bone was discussed.
【学位授予单位】：南京理工大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R816.8;R68

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