胶质瘤PET分子影像的应用进展

发布时间：2018-12-15 08:49

【摘要】：无创PET检查灵敏度高,能反映活体的代谢和分子水平,可通过糖代谢、氨基酸代谢、胆碱代谢、核酸代谢及乏氧等检测胶质瘤的代谢功能改变,在胶质瘤诊断、治疗和预后中发挥重要作用。~(18)F-脱氧葡萄糖(18F-fluorodeoxyglucose,~(18)F-FDG)显像的灵敏度高,但特异度较差。氨基酸显像可提供较好的肿瘤细胞增殖情况,胆碱、核酸显像能更敏感地从代谢方面反映胶质瘤的细胞增殖情况,乏氧显像则更有效地反映胶质瘤放化疗后的耐受情况。因此,PET能更好地指导胶质瘤活检取材、手术方案制订、放疗计划实施、疗效监测、鉴别复发与治疗后改变等。每一种显像剂均有各自优缺点,需综合应用于胶质瘤诊治研究。本综述总结了各类PET显像剂及其在胶质瘤诊断、预后、治疗及疗效监测中的作用。
[Abstract]:Noninvasive PET has high sensitivity and can reflect the metabolism and molecular level of gliomas in vivo. It can be used to detect the metabolic function of gliomas by glucose metabolism, amino acid metabolism, choline metabolism, nucleic acid metabolism and hypoxia. 18F-fluorodeoxyglucose ~ (18) F-FDG imaging has high sensitivity but poor specificity. Amino acid imaging can provide a good tumor cell proliferation, choline and nucleic acid imaging can more sensitively reflect the proliferation of glioma cells from the aspect of metabolism, and hypoxia imaging can more effectively reflect the tolerance of glioma after radiotherapy and chemotherapy. Therefore, PET can better guide the biopsy of glioma, the formulation of surgical plan, the implementation of radiotherapy plan, the monitoring of curative effect, the differentiation of recurrence and the changes after treatment, etc. Each imaging agent has its own advantages and disadvantages. This review summarizes various PET imaging agents and their role in the diagnosis, prognosis, treatment and monitoring of glioma.
【作者单位】：复旦大学附属华山医院PET中心;
【基金】：国家自然科学基金(No:81271516、81571345) 上海市科委项目(No:13JC1401503、14DZ1930400、14DZ1930402);上海市科委资助项目(No:16411968700) 复旦大学老年医学专项支持计划青年学者创新研究项目(No:IDF151006)
【分类号】：R739.41;R730.44

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