肝切除联合术中热消融治疗肝硬化背景下多灶性肝癌

发布时间：2018-12-17 21:01

【摘要】：目的探讨肝切除联合术中热消融治疗肝硬化背景下多灶性肝癌的有效性和安全性。方法回顾性分析63例接受肝切除联合术中热消融治疗肝硬化背景下多灶性肝癌患者的临床资料,分析患者的治疗效果及并发症。结果 63例患者共切除病灶85个,病灶平均最大直径(4.66±3.82)cm,热消融治疗病灶146个,病灶平均最大直径(1.48±0.66)cm。146个病灶完全消融率达100%(146/146),局部复发率4.11%(6/146)。患者1、2、3、4年无瘤生存率分别为54.82%、31.28%、12.03%、6.02%;1、3、5年累积生存率分别为83.51%、56.83%、45.20%。未出现治疗相关的死亡病例。肝切除相关严重并发症8例(8/63,12.70%)。未出现热消融相关严重并发症。结论肝切除联合术中热消融治疗肝硬化背景下多灶性肝癌安全、有效,扩大了肝切除术的适应证。
[Abstract]:Objective to evaluate the efficacy and safety of hepatectomy combined with intraoperative thermal ablation in the treatment of multifocal liver cancer in the context of cirrhosis. Methods the clinical data of 63 patients with multifocal liver cancer treated with hepatectomy combined with intraoperative thermal ablation were analyzed retrospectively. The therapeutic effects and complications of the patients were analyzed. Results Eighty-five lesions were resected in 63 patients. The mean maximum diameter of the lesions was (4.66 卤3.82) cm, thermal ablation for 146 lesions. The complete ablation rate of the lesions was 100% (146 / 146) with the mean maximum diameter of (1.48 卤0.66) cm.146. The local recurrence rate was 4.11% (6 / 146). The tumor-free survival rates were 54.82%, 31.28% and 12.03%, respectively, and the 5-year cumulative survival rates were 83.51%, 56.83% and 45.20%, respectively. There were no treatment-related deaths. Severe complications associated with hepatectomy were found in 8 cases (8 / 63, 12.70%). There were no serious complications associated with thermal ablation. Conclusion hepatectomy combined with intraoperative thermal ablation is safe and effective in the treatment of multifocal liver cancer in the background of liver cirrhosis, which expands the indication of hepatectomy.
【作者单位】： 天津市第三中心医院超声科天津市人工细胞重点实验室;天津市第三中心医院肝胆外科天津市人工细胞重点实验室;
【分类号】：R735.7;R730.44
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本文编号：2384792