肌内效贴对延迟性肌肉酸痛的疼痛缓解效果研究及其机制探讨

发布时间：2018-12-24 12:05

【摘要】：研究目的:本研究将采用不同恢复性干预手段对延迟性肌肉酸痛进行治疗干预,并对比治疗效果差异,旨在研究肌内效贴对延迟性肌肉酸痛的疼痛缓解效果,并尝试探讨其机制。研究方法:招募40名健康在校大学男生,将受试者随机分为5组,分别是肌内效贴治疗组、肌内效贴预防组、热疗组、安慰剂组和空白对照组。所有受试者均接受运动造模,产生延迟性肌肉酸痛(肌肉急性运动损伤),并在随后的96h内接受不同干预手段进行恢复治疗,分别为使用肌内效贴治疗、使用肌内效贴预防并治疗、使用热疗的方式治疗、使用无弹性普通贴布干预和不使用任何干预方式。通过观察受试者的血液指标(白细胞介素-6、肌酸激酶)和主观疼痛感受(Mc Gill量表、GPRS评分)的恢复变化情况,来评价肌内效贴的治疗效果并探讨潜在作用机制。研究结果:白细胞介素-6(IL-6)和肌酸激酶(CK)通过绘制恢复时间的ROC曲线并计算AUC后分析发现,肌内效贴治疗组和肌内效贴预防组IL-6恢复时间的AUC分别为0.727和0.695,优于热疗组的0.617和安慰剂对照组的0.641。肌内效贴治疗组CK恢复时间的AUC为0.672,优于其他三种干预组。主观疼痛感受分析采用RM ANOVA,肌内效贴预防组与空白对照组之间Mc Gill评分有统计学差异(p0.05);安慰剂对照组与空白对照组之间Mc Gill评分有统计学差异(p0.05)。对GPRS评分的分析发现,肌内效贴预防组与空白对照组之间有统计学差异(p0.05);热疗组与空白对照组之间有统计学差异(p0.05);安慰剂对照组与空白对照组之间有统计学差异(p0.05)。研究结论:使用肌内效贴能够促进运动损伤急性期的炎症反应恢复,并缩短损伤恢复时间;运动过程中使用肌内效贴能够减轻运动损伤后的炎症反应程度,因此具有较好的运动损伤预防效果。使用肌内效贴对运动损伤进行预防并治疗,能够显著缓解一次性大强度运动后的疼痛。其对于疼痛的缓解作用可能跟加速炎症反应恢复,抑制炎症反应细胞因子IL-6的释放有关。
[Abstract]:Objective: in this study, different restorative interventions were used to treat delayed muscle soreness, and the therapeutic effects were compared in order to study the analgesic effect of intramuscular paste on delayed muscle soreness. And try to explore its mechanism. Methods: forty healthy male students were recruited and randomly divided into 5 groups: intramuscular paste group, intramuscular patch prevention group, hyperthermia group, placebo group and blank control group. All the subjects were treated with motor modeling and delayed muscle soreness (acute muscle movement injury), and were treated with different intervention methods in the following 96 hours, which were treated with intramuscular patch. Use intramuscular plaster to prevent and treat, use hyperthermia therapy, use inelastic general patch intervention and no intervention. In order to evaluate the therapeutic effect and explore the potential mechanism of intramuscular patch, the changes of blood indexes (interleukin-6, creatine kinase) and subjective pain perception (Mc Gill scale (Mc Gill scale, GPRS score) were observed. Results: interleukin-6 (IL-6) and creatine kinase (CK) were analyzed by drawing ROC curve of recovery time and calculating AUC. The AUC of IL-6 recovery time in the intramuscular paste group and the intramuscular paste preventive group were 0.727 and 0.695, respectively, which were better than 0.617 in the hyperthermia group and 0.641 in the placebo group. The AUC of CK recovery time in the intramuscular paste group was 0.672, which was better than that in the other three intervention groups. Subjective pain perception analysis using RM ANOVA, intramuscular paste between the prevention group and the blank control group between the Mc Gill score was significantly different (p0.05), placebo control group and blank control group between the Mc Gill score was significantly different (p0.05). The analysis of GPRS score showed that there was significant difference between the prevention group and the blank control group (p0.05), the difference between the hyperthermia group and the blank control group was significant (p0.05), and the difference was significant between the hyperthermia group and the blank control group (p0.05). There was significant difference between placebo group and blank control group (p0.05). Conclusion: the application of intramuscular plaster can promote the recovery of inflammatory response and shorten the recovery time of injury in the acute stage of sports injury. The use of intramuscular paste during exercise can reduce the degree of inflammatory response after exercise injury, so it has a better preventive effect of exercise injury. The use of intramuscular paste to prevent and treat sports injuries can significantly relieve the pain after one-off high-intensity exercise. Its analgesic effect may be related to accelerating the recovery of inflammatory response and inhibiting the release of inflammatory cytokine IL-6.
【学位授予单位】：上海体育学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R87

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