鼻咽癌组织Raf-1的表达与鼻咽癌放疗敏感性的关系探讨

发布时间：2019-03-15 14:13

【摘要】：目的探讨鼻咽癌组织Raf-1的表达与鼻咽癌放疗敏感性的关系。方法选取72例鼻咽癌患者,根据患者放疗疗效分为放疗敏感患者37例(放疗敏感组),放疗抵抗患者(放疗抵抗组)35例,采用免疫组化染色检测两组Raf-1蛋白表达情况。结果两组患者性别、年龄、临床分期、组织分型及分化类型比较差异无统计学意义(P㧐0.05);放射敏感组Raf-1蛋白阳性表达率为29.73%,低于放射抵抗组的91.43%(P㩳0.05);放射敏感组Raf-1蛋白表达总体强度明显弱于放射抵抗组(P㩳0.05);Raf-1蛋白阳性表达预测鼻咽癌患者放疗抵抗的灵敏度为97.14%,特异度为70.27%,阳性预测值为75.56%,阴性预测值为96.29%。结论 Raf-1蛋白阳性表达率和表达强度与鼻咽癌放疗抵抗有关,对预测鼻咽癌放疗疗效有一定价值。
[Abstract]:Objective to investigate the relationship between the expression of Raf-1 and the radiosensitivity of nasopharyngeal carcinoma (NPC). Methods 72 patients with nasopharyngeal carcinoma (NPC) were divided into radiotherapy sensitive group (n = 37) and radiotherapy resistance group (n = 35) according to the curative effect of radiotherapy. The expression of Raf-1 protein in the two groups was detected by immunohistochemical staining. Results there was no significant difference in sex, age, clinical stage, histological type and differentiation type between the two groups (P < 0.05). The positive expression rate of Raf-1 protein in radiosensitive group was 29.73%, which was lower than that in radiation resistance group (91.43%), and the overall intensity of Raf-1 protein expression in radiosensitive group was significantly weaker than that in radioresistance group (P < 0.05). The sensitivity, specificity, positive predictive value and negative predictive value of Raf-1 protein expression were 97.14%, 70.27%, 75.56% and 96.29%, respectively. Conclusion the positive expression rate and intensity of Raf-1 protein are related to radiotherapy resistance of nasopharyngeal carcinoma, and it is valuable for predicting the curative effect of radiotherapy for nasopharyngeal carcinoma.
【作者单位】：广州医科大学附属肿瘤医院放疗三科;
【分类号】：R739.63;R730.55

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