五味子对高强度军事训练步兵应激系统的影响

发布时间：2018-01-06 20:01

本文关键词：五味子对高强度军事训练步兵应激系统的影响　出处：《解放军医学杂志》2014年01期 　论文类型：期刊论文

【摘要】：目的探讨五味子、红景天苷及复方五味子对军事应激前后人体下丘脑-垂体-肾上腺(HPA)轴、下丘脑-垂体-睾丸(HPG)轴和血清IL-1、IL-2、IL-6基础水平的影响。方法选择120名未经过较长期两栖作战训练的健康基层步兵作战部队官兵,随机分为复方五味子组(A组)、五味子组(B组)、红景天苷组(C组)、对照组(D组),每组30名。4组均进行每日8h的高强度复合军事训练,共持续1周。分别在训练前日和训练结束后次日清晨(7:00-8:00)静脉采血,采用放射性免疫分析法测定血清促肾上腺皮质激素(ACTH)、皮质醇(CORT)、睾酮(T)、IL-1、IL-2、IL-6水平并进行组间比较。结果对照组中,训练后的血清CORT和ACTH基础水平与训练前比较无明显差异(P0.05),而T水平明显下降(P0.01),IL-2水平明显上升(P0.05),IL-6水平明显下降(P0.01),IL-1水平比训练前亦有所升高,但差异无统计学意义。五味子组中,训练后的ACTH、T及IL-6水平较训练前明显下降,而IL-2水平明显升高(P0.01),CORT有下降趋势,但差异无统计学意义(P0.05)。红景天苷组中,训练后的T水平及IL-6水平较训练前明显下降(P0.01),CORT有下降趋势,但差异无统计学意义(P0.05)。复方五味子组中,训练之后的血清CORT、ACTH、T水平及IL-1、IL-6水平均明显下降,而IL-2水平明显升高(P0.01)。训练前各组之间各激素与细胞因子水平差异均无统计学意义(P0.05)。训练后五味子组和复方五味子组血清ACTH水平及红景天苷组血清IL-2水平与对照组比较明显下降(P0.05)。结论五味子及复方五味子对应激后HPA轴的抑制作用显著而持久,减弱了应激反应导致的CORT和ACTH水平升高,五味子复方中药可减轻应激导致的HPG轴的抑制,而红景天苷能明显减弱应激引起的IL-2水平升高。
[Abstract]:Objective to investigate the effects of Schisandra chinensis, salidroside and compound Schisandra chinensis on human hypothalamus-pituitary-adrenal (HPA) axis, hypothalamus-pituitary-testicular HPG axis and serum IL-1 before and after military stress. Methods 120 healthy basic infantry troops without long-term amphibious combat training were randomly divided into two groups: group A (compound Schisandra chinensis group). Group B of Schisandra chinensis group, group C of salidroside group and group D of control group were treated with high-intensity combined military training for 8 hours per day. The blood samples were collected from vein at 7: 00-8: 00 on the day before training and the morning after training. The serum ACTH was determined by radioimmunoassay (RIA). The levels of IL 2 and IL 2 were compared between the two groups. Results in the control group, the levels of IL 2 and IL 2 were compared between the two groups. After training, the basic levels of serum CORT and ACTH were not significantly different from those before training (P 0.05), but T levels decreased significantly (P 0.01). The level of IL-2 was significantly higher than that before training, but the difference was not statistically significant. In Schisandra group, the level of IL-1 was significantly lower than that of before training, but the level of IL-1 in Schisandra chinensis group was higher than that before training. After training, the levels of ACTH T and IL-6 decreased significantly compared with those before training, while the level of IL-2 increased significantly (P 0.01) and Cort decreased. In the salidroside group, the levels of T and IL-6 decreased significantly after training compared with those before training. But the difference was not statistically significant (P 0.05). In the compound Schisandra chinensis group, the serum levels of CTH T and IL 1 IL-6 decreased significantly after training. However, the level of IL-2 increased significantly (P 0.01). There was no significant difference in the levels of hormones and cytokines between the groups before training (P 0.05). After training, the serum ACTH levels of Schisandra chinensis group and compound Schisandra chinensis group and the serum IL-2 level of salidroside group decreased significantly compared with the control group (P 0.05). Conclusion the inhibitory effect of Schisandra chinensis and compound Schisandra chinensis on HPA axis after stress is significant and lasting. The levels of CORT and ACTH were decreased induced by stress reaction, and Schisandra chinensis compound could reduce the inhibition of HPG axis induced by stress. Salidroside could significantly attenuate the increase of IL-2 level induced by stress.
【作者单位】：南京大学附属南京军区总医院内分泌科;
【基金】：全军“十二五”科研基金面上项目(CWS11J252)~~
【分类号】：R82
【正文快照】： 适度的应激往往可活化思维,提高军人的警觉性和作业效率并较好地适应环境,然而,不适当或过度应激则会损害人体健康,引起一系列内分泌、代谢、自身免疫和精神功能方面的紊乱[1-2],进而引起疾病的发生。本课题组前期研究表明,五味子和红景天苷对应激反应导致的大鼠下丘脑-垂体-

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