西安市军队老年人慢性阻塞性肺疾病死亡危险因素的18年队列研究

发布时间：2018-02-04 18:59

本文关键词： 慢性阻塞性肺病队列研究戒烟　出处：《中华流行病学杂志》2006年09期 　论文类型：期刊论文

【摘要】：目的探讨西安市军队男性老年人慢性阻塞性肺病(COPD)死亡危险因素及相互关系。方法研究对象为1987年西安市22个军队干休所的全部男性离休干部,共计1268人。终点指标为全死因和COPD死亡。结果截止2005年6月30日,共观察18 766．28人年,平均随访14．35年;死亡491例,748人存活,29人失访。死亡总例数中COPD居第二位,占16．90％;COPD单因素分析:年龄的RR值95％CI为[1．13(1．09～1．17)]、每日吸烟量[1．04(1．02～1．06)]、吸烟年限[1．03 (1．01～1．04)]、负性生活事件[1．81(2．85～6．77)]、既往COPD史[4．39(2.85～6．77)]为COPD死亡危险因素;多因素分析结果显示:年龄的RR值95％CI为[1．10(1．06～1．15)]、每日吸烟量[1．03 (1_01～1．06)]、既往COPD史[3．07(1．90～4．98)]为COPD死亡危险因素;其死亡危险性随既往吸烟量的增多和吸烟年限的延长而升高,存在明确的剂量反应关系;戒烟者总死亡的危险下降了66．67％。结论队列中COPD死亡居第二位;年龄、每日吸烟量和既往COPD史是COPD死亡的危险因素;戒烟对COPD死亡的影响有待进一步观察。
[Abstract]:Objective to investigate the Xi'an army male senile chronic obstructive pulmonary disease (COPD) risk factors of death and the relationship between all men. Methods 22 military retired cadres retired cadres in Xi'an city in 1987, a total of 1268 people. The end point index for all causes of death and the death of COPD. Results the ending in June 30, 2005, a total of 18766.28 person years, average 14.35 years of follow-up; 491 cases died, 748 survived and 29 were lost. The total number of cases of COPD death in the second, accounting for 16.90%; single factor analysis: COPD age RR value of 95%CI is [1.13 (1.09 ~ 1.17), daily smoking amount [1.04 (1.02 ~ 1.06), [1.03 (duration of smoking from 1.01 to 1.04), negative life events of [1.81 (2.85 ~ 6.77), history of COPD [4.39 (2.85 ~ 6.77)] death risk factors for COPD; multivariate analysis showed that age RR value of 95%CI is [1.10 (1.06 ~ 1.15), daily smoking Smoke quantity [1.03 (1_01 ~ 1.06), history of COPD [3.07 (1.90 ~ 4.98)] death risk factors for COPD; extension increased its risk of death with past smoking amount and duration of smoking increased, there are clear dose-response relationship; risk of smokers total death decreased by COPD 66.67. Conclusion the queue in death ranks second; age, smoking and history of COPD COPD is a risk factor for death; smoking effects on COPD death needs to be further observed.

【作者单位】：
【分类号】：R82
【正文快照】： 我国慢性阻塞性肺病(COPD)有关危险因素的报告多为病例对照研究，其样本主要来源于医院病例，，代表性较差。关于吸烟、戒烟与COPD的前瞻性研究较少，目前仅见谢高强等[‘了对慢性支气管炎(‘漫支)患者进行的8年随访调查，认为戒烟可使吸烟者慢支发病危险降低至近似于不吸烟者

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