低G锻炼对高G致大鼠记忆功能和平衡能力变化的影响

发布时间：2018-02-11 05:20

本文关键词： 正加速度记忆平衡锻炼　出处：《航天医学与医学工程》2004年01期 　论文类型：期刊论文

【摘要】：目的探讨低G锻炼对高G致大鼠记忆功能和平衡能力改变的影响。方法 32只雄性SD大鼠随机分为对照组、+ 1 0Gz/5min组、锻炼 3d组和锻炼 5d组 4组 ,每组 8只。锻炼组分别在 + 1 0Gz/5min暴露前进行 3d或 5d的 + 4Gz/3min锻炼 ( 1次 /d)。观察单次 + 1 0Gz/5min暴露后即刻、1d、2d、4d和 6d大鼠记忆功能和平衡能力的变化。结果 + 1 0Gz组大鼠在 +Gz暴露后各时间点正确率较对照组均显著降低 (P 0 .0 1 ) ,反应时均显著延长 (P 0 .0 1 ) ,平衡能力在暴露后即刻及 2d时显著变差(P 0 .0 1 )。 + 4Gz/3min锻炼 3d组正确率在暴露后 1d、2d和 6d较对照组显著降低 (P 0 .0 5 ) ,在2d、4d和 6d时较 + 1 0Gz组显著升高 (P 0 .0 1 ) ;反应时在暴露后各时间点较对照组均显著延长 (P0 .0 5 ) ,在 1d、2d、4d和 6d时较 + 1 0Gz组显著缩短 (P 0 .0 1 ) ;平衡能力在暴露后即刻及 2d时较+ 1 0Gz组显著好转 (P 0 .0 1 )。 + 4Gz/3min锻炼 5d组正确率和反应时在暴露后各时间点较对照组均无显著差异 ;在暴露后 1d、2d、4d和 6d较 + 1 0Gz组显著改善 (P 0 .0 1 ) ;平衡能力在暴露后即刻及 2d时较 + 1 0Gz组显著好转 (P 0 .0 1 )。结论 + 4Gz/3min锻炼对高G致大鼠记忆功能损害和平衡能力具有一定的保护作用。
[Abstract]:Objective to investigate the effect of low G exercise on memory function and balance ability of rats induced by high G. Methods 32 male SD rats were randomly divided into control group, 10 Gz / 5 min group, 3 day exercise group and 5 day exercise group. There were 8 rats in each group. The rats in the exercise group were given 4 Gz / 3 min exercise for 3 days or 5 days before exposure to 10 Gz / 5 min. The memory function and balance ability of the rats were observed immediately after 10 Gz / 5 min exposure for 4 days and 6 days. The correct rate of 10 Gz group at all time points after Gz exposure was significantly lower than that of control group (P 0. 01). The response time was significantly prolonged (P 0. 01), and the balance ability became worse immediately after exposure and 2 days after exposure. The accuracy rate of 3d exercise group with 4 Gz / 3 min was significantly lower than that of the control group on the 1st day, 2nd day and 6th day after exposure (P 0. 05). P0. 01 (P 0. 01) was significantly increased at 2 d and 6 d compared with 10 Gz group, P 0. 0. 0 5 at each time point after exposure, and significantly shorter than that of 10 Gz group at 1 d, 2 d and 6 d, and P 0. 0 1 at 1 d, 2 d and 6 d, respectively. There was no significant difference in the correct rate and reaction time between the control group and the control group in the balance ability at the moment after exposure and at 2 days after exposure compared with that in the 10 Gz group (P 0. 01). 4 Gz / 3 min exercise for 5 d group showed no significant difference in correct rate and reaction time compared with the control group. At 1 d, 2 d and 6 d after exposure, it was significantly improved than that of 1.0 Gz group (P 0. 01). The balance ability was significantly better than that of 1.0 Gz group immediately after exposure and 2 days after exposure. Conclusion 4Gz / 3 min exercise has a certain protective effect on memory impairment and balance ability of rats induced by high G. [WT5HZ] [WT5BZ] [WT5BZ] [WT5 "BZ] [WT5" BZ] [WT5 "BZ]
【作者单位】：第四军医大学航空航天医学系航空航天生物动力学教研室第四军医大学航空航天医学系航空航天生物动力学教研室第四军医大学航空航天医学系航空航天生物动力学教研室第四军医大学航空航天医学系航空航天生物动力学教研室第四军医大学航空航天医学系航空航天生物动力学教研室第四军医大学航空航天医学系航空航天生物动力学教研室
【基金】：国家自然科学基金资助项目 ( 3 980 0 15 8) 军队回国人员科研启动基金 ( 0 1H0 2 8)
【分类号】：R85

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