长期摄入低剂量贫铀对大鼠血象与肝肾功能的影响

发布时间：2018-03-21 13:27

本文选题：贫铀　切入点：血常规　出处：《第三军医大学学报》2007年17期 　论文类型：期刊论文

【摘要】：目的研究长期摄入低剂量贫铀对大鼠的血象、肝肾功能的影响。方法给予初断乳大鼠含贫铀饲料,摄入贫铀的剂量分别为0、0.4、4、40mg·kg-1·d-1,随后的14个月内,临床生化自动检测仪测定外周血、肝肾功能的变化。结果F0代:小剂量组在14个月、中剂量组在10个月、高剂量组在7个月;F1代:中、高剂量组在10个月时出现白细胞显著降低,并由这些时相点开始出现各项血液学指标持续下降。随摄入贫铀剂量的增加,摄入时间的延长,白细胞和红细胞计数出现下降的时间越早,降幅越大;同一剂量组同一时相点,F1代比F0代降得更低。实验组肝功能与正常组没有显著差异(P0.05)。肾功能指标仅有某个时相点血清肌酐上升,其余变化不显著(P0.05)。结论长期摄入低剂量贫铀,只有在较长期或剂量较大时,可使外周血白细胞下降,继而红细胞、血小板计数下降;肾功能影响轻微,肝功能无影响。
[Abstract]:Objective to study the effect of long-term intake of low dose depleted uranium on the blood picture, liver and kidney function of rats. Methods the rats were fed with depleted uranium diet at the dose of 0.40 mg 路kg-1 路d -1, respectively. The peripheral blood was measured by clinical biochemical automatic detector within 14 months. Results the changes of liver and kidney function in F0 group: low dose group in 14 months, middle dose group in 10 months, high dose group in 7 months and F1 generation. With the increase of the dosage of depleted uranium and the prolongation of the ingestion time, the earlier the white blood cell and erythrocyte count decreased, the greater the decline. The liver function of the experimental group was not significantly different from that of the normal group (P 0.05). The serum creatinine level was increased only at a certain point in the renal function index, while the other changes were not significant (P 0.05). Conclusion the long-term intake of low dose depleted uranium is not significant. Only in the longer term or the larger dose, the peripheral blood leukocyte decreased, then the red blood cell, the platelet count decreased, the renal function influence was slight, the liver function had no effect.
【作者单位】：第三军医大学军事预防医学院防原医学教研室全军复合伤研究所
【基金】：国家自然科学基金(30670625) 中国博士后科学基金(20060390680) 全军医学科研“十一五”计划专项课题(06Z031)~~
【分类号】：R82

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