drug interaction mechanisms traditionalChinese medicine

  本文关键词：传统药物对西药药代动力学影响的研究与探索，由笔耕文化传播整理发布。

传统药物对西药药代动力学影响的研究与探索

An overview of effects of traditional medicine on pharmacokinetics of western medicine

[1] [2] [3]

ZHEN Ya-qin, KONG De-zhi, REN Lei-ming （Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang 050017, China ）

河北医科大学中西医结合研究所,河北石家庄050017

文章摘要：近20年来草药（或称植物药、传统药）的使用再次盛行，据调查以草药作为补充和替代药物的人群占世界人口的70％，近10年的数据显示，加拿大、澳大利亚以及欧洲的草药消耗量以指数形式增长。特别是草药与西药同时服用己成为一种趋势，，草药与西药联合应用是一个需要引起高度重视的问题，国际上已有大量文献、临床报告、动物实验对草药-西药相互作用进行了广泛的研究，临床上对草药-西药相互作用的问题也日益关注。本文综述了临床上草药与西药联合应用时所产生的相互作用，及其对患者病情及治疗影响的研究。研究内容包括草药-西药相互作用的临床表现、循证医学研究和证据等级标准的建立；在作用机制方面包括药物代谢酶的诱导与抑制、转运体的诱导与抑制、胃肠道功能的改变、肾脏清除药物能力的改变等。本文还介绍了国内当前中药-西药联合用药的现状和存在的问题。

Abstr：Traditional medicine （herb medicine） began to prevail again over last two decades, and it is about 70% of the world population taking herb medicine as supplement or alternative medicine according to a recent survey. The consumption of herb medicine increased exponentially in Canada, Australia and Europe during last 10 years. Since concomitant administration of herbal and western medicine has become a trend, it requires paying close attention to the problem. Herb-drug interactions have been extensively investigated worldwide, and there is an increasing concern about the clinical herb-drug interaction. In this review we introduced the current progress in the herb-drug interactions including evidence-based clinical studies and establishment of levels of evidence for herb-drug interaction; and in the related mechanisms including the induction and inhibition of metabolic enzymes, inhibition and induction of transport and efflux proteins, alteration of gastrointestinal functions, and alteration in renal elimination. We also analyzed both the achievements and the challenges faced in the concomitant administration of traditional Chinese medicine and western medicine.

文章关键词：

Keyword：:herbal medicine concomitant administration herb-drug interaction mechanisms traditionalChinese medicine

课题项目：国家重点基础研究发展计划（973计划）资助项目（2012CB518601）;国家科技部“重大新药创制”科技重大专项资助项目（2011ZX09102-011-04）.

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  本文关键词：传统药物对西药药代动力学影响的研究与探索，由笔耕文化传播整理发布。